Directed cell invasion and migration during metastasis

Jose Javier Bravo-Cordero, Louis Hodgson, John S. Condeelis

Research output: Contribution to journalArticle

207 Citations (Scopus)

Abstract

Metastasis requires tumor cell dissemination to different organs from the primary tumor. Dissemination is a complex cell motility phenomenon that requires the molecular coordination of the protrusion, chemotaxis, invasion and contractility activities of tumor cells to achieve directed cell migration. Recent studies of the spatial and temporal activities of the small GTPases have begun to elucidate how this coordination is achieved. The direct visualization of the pathways involved in actin polymerization, invasion and directed migration in dissemination competent tumor cells will help identify the molecular basis of dissemination and allow the design and testing of more specific and selective drugs to block metastasis.

Original languageEnglish (US)
Pages (from-to)277-283
Number of pages7
JournalCurrent Opinion in Cell Biology
Volume24
Issue number2
DOIs
StatePublished - Apr 2012

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Cell Movement
Neoplasm Metastasis
Neoplasms
Monomeric GTP-Binding Proteins
Chemotaxis
Polymerization
Actins
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Cell Biology

Cite this

Directed cell invasion and migration during metastasis. / Bravo-Cordero, Jose Javier; Hodgson, Louis; Condeelis, John S.

In: Current Opinion in Cell Biology, Vol. 24, No. 2, 04.2012, p. 277-283.

Research output: Contribution to journalArticle

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