Directed cell invasion and migration during metastasis

Jose Javier Bravo-Cordero, Louis Hodgson, John Condeelis

Research output: Contribution to journalReview article

244 Scopus citations

Abstract

Metastasis requires tumor cell dissemination to different organs from the primary tumor. Dissemination is a complex cell motility phenomenon that requires the molecular coordination of the protrusion, chemotaxis, invasion and contractility activities of tumor cells to achieve directed cell migration. Recent studies of the spatial and temporal activities of the small GTPases have begun to elucidate how this coordination is achieved. The direct visualization of the pathways involved in actin polymerization, invasion and directed migration in dissemination competent tumor cells will help identify the molecular basis of dissemination and allow the design and testing of more specific and selective drugs to block metastasis.

Original languageEnglish (US)
Pages (from-to)277-283
Number of pages7
JournalCurrent Opinion in Cell Biology
Volume24
Issue number2
DOIs
StatePublished - Apr 1 2012

ASJC Scopus subject areas

  • Cell Biology

Fingerprint Dive into the research topics of 'Directed cell invasion and migration during metastasis'. Together they form a unique fingerprint.

  • Cite this