TY - JOUR
T1 - Direct relationship of local C-reactive protein production and lipid pool characterized by integrated backscatter intravascular ultrasound
T2 - A preliminary observation
AU - Kobayashi, Yuhei
AU - Okura, Hiroyuki
AU - Kume, Teruyoshi
AU - Miyamoto, Yoshinori
AU - Yamada, Ryotaro
AU - Kobayashi, Yukari
AU - Fukuhara, Kenzo
AU - Koyama, Terumasa
AU - Neishi, Yoji
AU - Yoshida, Kiyoshi
N1 - Publisher Copyright:
© 2015 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2015/7/11
Y1 - 2015/7/11
N2 - Background Local production of C-reactive protein (CRP) in human coronary arterial plaque was reported as a possible marker for local inflammation and vulnerable plaque. Integrated backscatter intravascular ultrasound (IB-IVUS) plaque tissue characterization may detect vulnerable plaque with high local plaque inflammation. Thus, the aim of this study was to clarify the relationship between IB-IVUS-based plaque characteristics and local high-sensitivity C-reactive protein (hs-CRP) production in stable and unstable plaque. Methods and results Eighteen patients (nine unstable angina/non-ST-segment elevation myocardial infarction and nine stable angina) were prospectively enrolled. Using the microcatheter, blood samples from the proximal and distal sites of the culprit lesion were obtained to measure local CRP production. Translesional hs-CRP was defined as distal hs-CRP minus proximal hs-CRP of the culprit lesion. Gray-scale and IB-IVUS analyses were carried out at the target lesion. The translesional hs-CRP level tended to be higher in the unstable angina group than in the stable angina group (0.026±0.033 vs. 0.003±0.007 mg/dl, P=0.050). Gray-scale IVUS-derived indices did not correlate with translesional hs-CRP. However, % lipid pool area by IB-IVUS correlated positively (r=0.54, P=0.02) and % fibrosis area correlated negatively with the translesional hs-CRP level (r=-0.52, P=0.03). Conclusion Lipid pool area detected by IB-IVUS is correlated positively with the translesional hs-CRP level.
AB - Background Local production of C-reactive protein (CRP) in human coronary arterial plaque was reported as a possible marker for local inflammation and vulnerable plaque. Integrated backscatter intravascular ultrasound (IB-IVUS) plaque tissue characterization may detect vulnerable plaque with high local plaque inflammation. Thus, the aim of this study was to clarify the relationship between IB-IVUS-based plaque characteristics and local high-sensitivity C-reactive protein (hs-CRP) production in stable and unstable plaque. Methods and results Eighteen patients (nine unstable angina/non-ST-segment elevation myocardial infarction and nine stable angina) were prospectively enrolled. Using the microcatheter, blood samples from the proximal and distal sites of the culprit lesion were obtained to measure local CRP production. Translesional hs-CRP was defined as distal hs-CRP minus proximal hs-CRP of the culprit lesion. Gray-scale and IB-IVUS analyses were carried out at the target lesion. The translesional hs-CRP level tended to be higher in the unstable angina group than in the stable angina group (0.026±0.033 vs. 0.003±0.007 mg/dl, P=0.050). Gray-scale IVUS-derived indices did not correlate with translesional hs-CRP. However, % lipid pool area by IB-IVUS correlated positively (r=0.54, P=0.02) and % fibrosis area correlated negatively with the translesional hs-CRP level (r=-0.52, P=0.03). Conclusion Lipid pool area detected by IB-IVUS is correlated positively with the translesional hs-CRP level.
KW - intravascular ultrasound
KW - percutaneous coronary intervention
KW - translesional high-sensitivity C-reactive protein
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U2 - 10.1097/MCA.0000000000000250
DO - 10.1097/MCA.0000000000000250
M3 - Article
C2 - 25886998
AN - SCOPUS:84936930565
SN - 0954-6928
VL - 26
SP - 425
EP - 431
JO - Coronary Artery Disease
JF - Coronary Artery Disease
IS - 5
ER -