Dips in dopamine say “no” to nicotine

Alice Servonnet; Saleem M. Nicola

doi:10.1016/j.neuron.2022.08.021

Dips in dopamine say “no” to nicotine

Alice Servonnet, Saleem M. Nicola

Neuroscience

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Nicotine has both rewarding and aversive effects. In this issue of Neuron, Liu et al. show that nicotine aversion depends on both desensitization of high-affinity nicotinic acetylcholine receptors (nAChRs) that activate midbrain dopamine neurons and activation of low-affinity nAChRs that inhibit dopamine neurons via the laterodorsal tegmental nucleus (LDT).

Original language	English (US)
Pages (from-to)	2895-2898
Number of pages	4
Journal	Neuron
Volume	110
Issue number	18
DOIs	https://doi.org/10.1016/j.neuron.2022.08.021
State	Published - Sep 21 2022

ASJC Scopus subject areas

Neuroscience(all)

Access to Document

10.1016/j.neuron.2022.08.021

Cite this

@article{cf3ccc4757944c9f8bc8535596954892,

title = "Dips in dopamine say “no” to nicotine",

abstract = "Nicotine has both rewarding and aversive effects. In this issue of Neuron, Liu et al. show that nicotine aversion depends on both desensitization of high-affinity nicotinic acetylcholine receptors (nAChRs) that activate midbrain dopamine neurons and activation of low-affinity nAChRs that inhibit dopamine neurons via the laterodorsal tegmental nucleus (LDT).",

author = "Alice Servonnet and Nicola, {Saleem M.}",

note = "Funding Information: The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

year = "2022",

month = sep,

day = "21",

doi = "10.1016/j.neuron.2022.08.021",

language = "English (US)",

volume = "110",

pages = "2895--2898",

journal = "Neuron",

issn = "0896-6273",

publisher = "Cell Press",

number = "18",

}

TY - JOUR

T1 - Dips in dopamine say “no” to nicotine

AU - Servonnet, Alice

AU - Nicola, Saleem M.

PY - 2022/9/21

Y1 - 2022/9/21

N2 - Nicotine has both rewarding and aversive effects. In this issue of Neuron, Liu et al. show that nicotine aversion depends on both desensitization of high-affinity nicotinic acetylcholine receptors (nAChRs) that activate midbrain dopamine neurons and activation of low-affinity nAChRs that inhibit dopamine neurons via the laterodorsal tegmental nucleus (LDT).

AB - Nicotine has both rewarding and aversive effects. In this issue of Neuron, Liu et al. show that nicotine aversion depends on both desensitization of high-affinity nicotinic acetylcholine receptors (nAChRs) that activate midbrain dopamine neurons and activation of low-affinity nAChRs that inhibit dopamine neurons via the laterodorsal tegmental nucleus (LDT).

UR - http://www.scopus.com/inward/record.url?scp=85138096976&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85138096976&partnerID=8YFLogxK

U2 - 10.1016/j.neuron.2022.08.021

DO - 10.1016/j.neuron.2022.08.021

M3 - Comment/debate

C2 - 36137519

AN - SCOPUS:85138096976

SN - 0896-6273

VL - 110

SP - 2895

EP - 2898

JO - Neuron

JF - Neuron

IS - 18

ER -

Dips in dopamine say “no” to nicotine

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this