Dimeric Lea (Lea-on-Lea) status of ß-haptoglobin in sera of colon cancer, chronic inflammatory disease and normal subjects

Seung Yeol Park, Seon Joo Yoon, Sen Itiroh Hakomori, Jin Man Kim, Ji Yeon Kim, Bradford Bernert, Thomas Ullman, Steven H. Itzkowitz, Jung Hoe Kim

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The glycosyl epitope dimeric Lea (Lea-on-Le a), defined by mouse monoclonal antibody NCC-ST-421, was identified previously as tumor-associated antigen, expressed highly in various human cancer tissues and cell lines derived therefrom, but with minimal expression in various normal tissues. In the present study, we observed clearly higher expression of this epitope, defined by ST421, in ß-haptoglobin (ß-Hap) from sera of patients with colorectal cancer, compared to normal, healthy subjects or patients with chronic inflammatory processes (Crohn's disease, ulcerative colitis).

Original languageEnglish (US)
Pages (from-to)1291-1297
Number of pages7
JournalInternational journal of oncology
Volume36
Issue number5
DOIs
StatePublished - May 1 2010
Externally publishedYes

Keywords

  • Colon cancer
  • Dimeric Le
  • Haptoglobin
  • Lectin blotting
  • O-linked glycan

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Park, S. Y., Yoon, S. J., Hakomori, S. I., Kim, J. M., Kim, J. Y., Bernert, B., Ullman, T., Itzkowitz, S. H., & Kim, J. H. (2010). Dimeric Lea (Lea-on-Lea) status of ß-haptoglobin in sera of colon cancer, chronic inflammatory disease and normal subjects. International journal of oncology, 36(5), 1291-1297. https://doi.org/10.3892/ijo-00000614