Digging a little deeper

the stages of invadopodium formation and maturation

Brian T. Beaty, John S. Condeelis

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Invadopodia are actin-rich protrusions that degrade the extracellular matrix and are required for penetration through the basement membrane, stromal invasion and intravasation. Invadopodia are enriched in actin regulators, such as cortactin, cofilin, N-WASp, Arp2/3 and fascin. Much of the work to date has centered around identifying the proteins involved in regulating actin polymerization and matrix degradation. Recently, there have been significant advances in characterization of the very early stages of invadopodium precursor assembly and the role of adhesion proteins, such as β1 integrin, talin, FAK and Hic-5, in promoting invadopodium maturation. This review summarizes these findings in the context of our current model of invadopodial function and highlights some of the important unanswered questions in the field.

Original languageEnglish (US)
Pages (from-to)438-444
Number of pages7
JournalEuropean Journal of Cell Biology
Volume93
Issue number10-12
DOIs
StatePublished - Oct 1 2014

Fingerprint

Actins
Cortactin
Talin
Actin Depolymerizing Factors
Basement Membrane
Integrins
Polymerization
Extracellular Matrix
Proteins
Podosomes
fascin

Keywords

  • Arg
  • Cdc42
  • Cofilin
  • Invadopodia
  • Invasion
  • Metastasis
  • Moesin
  • NHE-1
  • Talin
  • β1 integrin

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Digging a little deeper : the stages of invadopodium formation and maturation. / Beaty, Brian T.; Condeelis, John S.

In: European Journal of Cell Biology, Vol. 93, No. 10-12, 01.10.2014, p. 438-444.

Research output: Contribution to journalArticle

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