Diffuse sebaceous-gland hyperplasia

Diffuse sebaceous-gland hyperplasia is a rare variant of sebaceous-gland hyperplasia that is distinct from the well-known circumscribed type. The term presenile sebaceous hyperplasia has been utilized to describe this entity that is distinguished by specific features, which include confluence of lesions that results in the formation of large plaques on the face, the sparing of periorificial regions, and highly functional glandular hyperplasia that results in excessive sebaceous secretion. We present a 43-year-old woman with monomorphous, skincolored and yellow, smooth 1- to-3-mm papules, some with central umbilication, that spare the periorificial zones. Histopathologic examination was suggestive of diffuse sebaceous-gland hyperplasia. Differential diagnosis of this condition is broad and includes syndromes that are associated with multiple facial papules and malignant conditions, such as Muire-Torre syndrome and Cowden syndrome. It is important to be aware of this condition in order to consider appropriate treatment options, such as isotretinoin and to avoid unnecessary diagnostic tests.