Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones

Padmini Salgame, John S. Abrams, Carol Clayberger, Harris Goldstein, Jacinto Convit, Robert L. Modlin, Barry R. Bloom

Research output: Contribution to journalArticle

934 Citations (Scopus)

Abstract

Functional subsets of human T cells were delineated by analyzing patterns of lymphokines produced by clones from individuals with leprosy and by T cell clones of known function. CD4 clones from individuals with strong cell-mediated immunity produced predominantly interferon-γ, whereas those clones that enhanced antibody formation produced interleukin-4. CD8 cytotoxic T cells secreted interferon-γ. Interleukin-4 was produced by CD8 T suppressor clones from immunologically unresponsive individuals with leprosy and was found to be necessary for suppression in vitro. Both the classic reciprocal relation between antibody formation and cell-mediated immunity and resistance or susceptibility to certain infections may be explained by T cell subsets differing in patterns of lymphokine production.

Original languageEnglish (US)
Pages (from-to)279-282
Number of pages4
JournalScience
Volume254
Issue number5029
StatePublished - Oct 11 1991

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Lymphokines
Clone Cells
T-Lymphocytes
T-Lymphocyte Subsets
Leprosy
Cellular Immunity
Interleukin-4
Interferons
Antibody Formation
Infection

ASJC Scopus subject areas

  • General

Cite this

Salgame, P., Abrams, J. S., Clayberger, C., Goldstein, H., Convit, J., Modlin, R. L., & Bloom, B. R. (1991). Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science, 254(5029), 279-282.

Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. / Salgame, Padmini; Abrams, John S.; Clayberger, Carol; Goldstein, Harris; Convit, Jacinto; Modlin, Robert L.; Bloom, Barry R.

In: Science, Vol. 254, No. 5029, 11.10.1991, p. 279-282.

Research output: Contribution to journalArticle

Salgame, P, Abrams, JS, Clayberger, C, Goldstein, H, Convit, J, Modlin, RL & Bloom, BR 1991, 'Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones', Science, vol. 254, no. 5029, pp. 279-282.
Salgame P, Abrams JS, Clayberger C, Goldstein H, Convit J, Modlin RL et al. Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science. 1991 Oct 11;254(5029):279-282.
Salgame, Padmini ; Abrams, John S. ; Clayberger, Carol ; Goldstein, Harris ; Convit, Jacinto ; Modlin, Robert L. ; Bloom, Barry R. / Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. In: Science. 1991 ; Vol. 254, No. 5029. pp. 279-282.
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