Differentiation of columnar epithelia

The hensin pathway

Soundarapandian Vijayakumar, Jiro Takito, Xiaobo Gao, George J. Schwartz, Qais Al-Awqati

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Epithelia, the most common variety of cells in complex organisms exist in many shapes. They are sheets of polarized cells that separate two compartments and selectively transport materials from one to the other. After acquiring these general characteristics, they differentiate to become specialized types such as squamous columnar or transitional epithelia. High density seeding converts a kidney-derived cell line from flat 'generic' epithelial cells to columnar cells. The cells acquire all the characteristics of differentiated columnar cells, including microvilli, and the capacity for apical endocytosis. The high seeding density induces the deposition of a new protein termed hensin and polymerization of hensin is the crucial event that dictates changes in epithelial phenotype. Hensin is widely expressed in most epithelia. Its deletion in mice leads to embryonic lethality at the time of generation of the first columnar epithelium, the visceral endoderm. Moreover many human cancers have deletions in the hensin gene, which indicates that it is a tumor suppressor.

Original languageEnglish (US)
Pages (from-to)4797-4801
Number of pages5
JournalJournal of cell science
Volume119
Issue number23
DOIs
StatePublished - Dec 1 2006
Externally publishedYes

Fingerprint

Epithelium
Endoderm
Microvilli
Endocytosis
Polymerization
Neoplasms
Epithelial Cells
Phenotype
Kidney
Cell Line
Genes
Proteins

Keywords

  • Columnar epithelia
  • DMBT1
  • Epithelial terminal differentiation
  • Hensin

ASJC Scopus subject areas

  • Cell Biology

Cite this

Vijayakumar, S., Takito, J., Gao, X., Schwartz, G. J., & Al-Awqati, Q. (2006). Differentiation of columnar epithelia: The hensin pathway. Journal of cell science, 119(23), 4797-4801. https://doi.org/10.1242/jcs.03269

Differentiation of columnar epithelia : The hensin pathway. / Vijayakumar, Soundarapandian; Takito, Jiro; Gao, Xiaobo; Schwartz, George J.; Al-Awqati, Qais.

In: Journal of cell science, Vol. 119, No. 23, 01.12.2006, p. 4797-4801.

Research output: Contribution to journalArticle

Vijayakumar, S, Takito, J, Gao, X, Schwartz, GJ & Al-Awqati, Q 2006, 'Differentiation of columnar epithelia: The hensin pathway', Journal of cell science, vol. 119, no. 23, pp. 4797-4801. https://doi.org/10.1242/jcs.03269
Vijayakumar S, Takito J, Gao X, Schwartz GJ, Al-Awqati Q. Differentiation of columnar epithelia: The hensin pathway. Journal of cell science. 2006 Dec 1;119(23):4797-4801. https://doi.org/10.1242/jcs.03269
Vijayakumar, Soundarapandian ; Takito, Jiro ; Gao, Xiaobo ; Schwartz, George J. ; Al-Awqati, Qais. / Differentiation of columnar epithelia : The hensin pathway. In: Journal of cell science. 2006 ; Vol. 119, No. 23. pp. 4797-4801.
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