Differential subcellular distribution of PC1, PC2 and furin in bovine adrenal medulla and secretion of PC1 and PC2 from this tissue

R. Kirchmair, C. Egger, P. Gee, R. Hogue-Angeletti, R. Fischer-Colbrie, A. Laslop, H. Winkler

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

The subcellular distribution of PC1, PC2 and furin was determined in bovine adrenal medulla by immunoblotting of fractions obtained by density gradient centrifugation. PC1 and PC2 were found to be confined to chromaffin granules whereas furin (C-terminal-peptide) was absent from these organelles. Stimulation of bovine adrenal medulla by carbamoylcholine chloride induced the secretion of PC1 and PC2. The secreted enzymes had the same molecular size as PC1 and PC2 present in chromaffin granules.

Original languageEnglish (US)
Pages (from-to)143-145
Number of pages3
JournalNeuroscience Letters
Volume143
Issue number1-2
DOIs
StatePublished - Aug 31 1992

Keywords

  • Chromaffin granule
  • Endopeptidase
  • Secretion

ASJC Scopus subject areas

  • Neuroscience(all)

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    Kirchmair, R., Egger, C., Gee, P., Hogue-Angeletti, R., Fischer-Colbrie, R., Laslop, A., & Winkler, H. (1992). Differential subcellular distribution of PC1, PC2 and furin in bovine adrenal medulla and secretion of PC1 and PC2 from this tissue. Neuroscience Letters, 143(1-2), 143-145. https://doi.org/10.1016/0304-3940(92)90252-3