Differential inhibition of adenosine deaminase deficient peripheral blood lymphocytes and lymphoid line cells by deoxyadenosine and adenosine

R. Hirschhorn; S. Bajaj; W. Borkowsky; A. Kowalski; R. Hong; A. Rubinstein; P. Papageorgiou

doi:10.1016/0008-8749(79)90207-7

Differential inhibition of adenosine deaminase deficient peripheral blood lymphocytes and lymphoid line cells by deoxyadenosine and adenosine

R. Hirschhorn, S. Bajaj, W. Borkowsky, A. Kowalski, R. Hong, A. Rubinstein, P. Papageorgiou

Pediatrics

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

The response to mitogens of peripheral blood lymphocytes (PBL) from adenosine deaminase deficient (ADA^-) patients with Severe Combined Immunodeficiency (SCID), but not from normals, was more sensitive to inhibition by deoxyadenosine than by adenosine. In contrast, proliferation of long-term lymphoid line (B) cells from these patients was essentially equally inhibited by adenosine and deoxyadenosine. Deoxycytidine could "rescue" ADA^- PBLs from deoxyadenosine toxicity.

Original language	English (US)
Pages (from-to)	418-423
Number of pages	6
Journal	Cellular Immunology
Volume	42
Issue number	2
DOIs	https://doi.org/10.1016/0008-8749(79)90207-7
State	Published - Feb 1979

ASJC Scopus subject areas

Immunology

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title = "Differential inhibition of adenosine deaminase deficient peripheral blood lymphocytes and lymphoid line cells by deoxyadenosine and adenosine",

abstract = "The response to mitogens of peripheral blood lymphocytes (PBL) from adenosine deaminase deficient (ADA-) patients with Severe Combined Immunodeficiency (SCID), but not from normals, was more sensitive to inhibition by deoxyadenosine than by adenosine. In contrast, proliferation of long-term lymphoid line (B) cells from these patients was essentially equally inhibited by adenosine and deoxyadenosine. Deoxycytidine could {"}rescue{"} ADA- PBLs from deoxyadenosine toxicity.",

author = "R. Hirschhorn and S. Bajaj and W. Borkowsky and A. Kowalski and R. Hong and A. Rubinstein and P. Papageorgiou",

note = "Funding Information: 1 Supported by Grants Al 10343 and HD 07778 from the National Institutes of Health. 2 W. Borkowsky is supported by USPHS Training Grant 5T01A100005-20.",

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language = "English (US)",

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T1 - Differential inhibition of adenosine deaminase deficient peripheral blood lymphocytes and lymphoid line cells by deoxyadenosine and adenosine

AU - Hirschhorn, R.

AU - Bajaj, S.

AU - Borkowsky, W.

AU - Kowalski, A.

AU - Hong, R.

AU - Rubinstein, A.

AU - Papageorgiou, P.

N1 - Funding Information: 1 Supported by Grants Al 10343 and HD 07778 from the National Institutes of Health. 2 W. Borkowsky is supported by USPHS Training Grant 5T01A100005-20.

PY - 1979/2

Y1 - 1979/2

N2 - The response to mitogens of peripheral blood lymphocytes (PBL) from adenosine deaminase deficient (ADA-) patients with Severe Combined Immunodeficiency (SCID), but not from normals, was more sensitive to inhibition by deoxyadenosine than by adenosine. In contrast, proliferation of long-term lymphoid line (B) cells from these patients was essentially equally inhibited by adenosine and deoxyadenosine. Deoxycytidine could "rescue" ADA- PBLs from deoxyadenosine toxicity.

AB - The response to mitogens of peripheral blood lymphocytes (PBL) from adenosine deaminase deficient (ADA-) patients with Severe Combined Immunodeficiency (SCID), but not from normals, was more sensitive to inhibition by deoxyadenosine than by adenosine. In contrast, proliferation of long-term lymphoid line (B) cells from these patients was essentially equally inhibited by adenosine and deoxyadenosine. Deoxycytidine could "rescue" ADA- PBLs from deoxyadenosine toxicity.

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Differential inhibition of adenosine deaminase deficient peripheral blood lymphocytes and lymphoid line cells by deoxyadenosine and adenosine

Abstract

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