Differential inhibition of adenosine deaminase deficient peripheral blood lymphocytes and lymphoid line cells by deoxyadenosine and adenosine

R. Hirschhorn, S. Bajaj, W. Borkowsky, A. Kowalski, R. Hong, A. Rubinstein, P. Papageorgiou

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The response to mitogens of peripheral blood lymphocytes (PBL) from adenosine deaminase deficient (ADA-) patients with Severe Combined Immunodeficiency (SCID), but not from normals, was more sensitive to inhibition by deoxyadenosine than by adenosine. In contrast, proliferation of long-term lymphoid line (B) cells from these patients was essentially equally inhibited by adenosine and deoxyadenosine. Deoxycytidine could "rescue" ADA- PBLs from deoxyadenosine toxicity.

Original languageEnglish (US)
Pages (from-to)418-423
Number of pages6
JournalCellular Immunology
Issue number2
StatePublished - Feb 1979


ASJC Scopus subject areas

  • Immunology

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