Differential inhibition of adenosine deaminase deficient peripheral blood lymphocytes and lymphoid line cells by deoxyadenosine and adenosine

R. Hirschhorn, S. Bajaj, W. Borkowsky, A. Kowalski, R. Hong, A. Rubinstein, P. Papageorgiou

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The response to mitogens of peripheral blood lymphocytes (PBL) from adenosine deaminase deficient (ADA-) patients with Severe Combined Immunodeficiency (SCID), but not from normals, was more sensitive to inhibition by deoxyadenosine than by adenosine. In contrast, proliferation of long-term lymphoid line (B) cells from these patients was essentially equally inhibited by adenosine and deoxyadenosine. Deoxycytidine could "rescue" ADA- PBLs from deoxyadenosine toxicity.

Original languageEnglish (US)
Pages (from-to)418-423
Number of pages6
JournalCellular Immunology
Volume42
Issue number2
DOIs
StatePublished - Feb 1979

ASJC Scopus subject areas

  • Immunology

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