Differential induction of chemokines in human microglia by type I and II interferons

Carrie M. McManus, Judy S H Liu, Matthew T. Hahn, Liwei L. Hua, Celia F. Brosnan, Joan W. Berman, Sunhee C. Lee

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Chemokines are secreted proteins that function as chemoattractants, mediating the recruitment of specific subsets of leukocytes to sites of tissue damage and immunological reactions. Chemokines may also function as antiviral agents, since viruses such as human immunodeficiency virus type 1 (HIV-1) use chemokine receptors as co-receptors for viral entry. This study examines whether virus-induced interferon, IFNβ, or immune-related interferon, IFNγ, affects the production of β-chemokines by CNS microglia and peripheral monocytes. When IFNβ was used as the stimulus, induction of MIP-1α, MIP-1β, MCP-1, and RANTES mRNA and protein was observed within 12 h of stimulation in microgila. By contrast, when IFNγ was used as the stimulus, only MCP-1 was induced. IFNβ stimulation of blood monocytes resulted in upregulation of MIP-1α, MIP-1β, and MCP-1. Thus, type I and II interferons differentially regulate β-chemokines in human fetal microglia and peripheral blood monocytes. These observations may have relevance for the therapeutic activity of IFNβ in multiple sclerosis and for the antiviral effects of IFNβ for HIV-1 infection of monocytes and microglia. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)273-280
Number of pages8
JournalGLIA
Volume29
Issue number3
DOIs
StatePublished - Feb 1 2000

Fingerprint

Interferon Type I
Microglia
Chemokines
Interferon-gamma
Monocytes
Antiviral Agents
HIV-1
Viruses
Chemokine CCL5
Chemokine Receptors
Chemotactic Factors
Virus Diseases
Interferons
Multiple Sclerosis
Proteins
Leukocytes
Up-Regulation
Messenger RNA
Therapeutics

Keywords

  • Chemokines
  • EAE/MS
  • HIV/AIDS
  • Human
  • Neuroimmunology

ASJC Scopus subject areas

  • Immunology

Cite this

Differential induction of chemokines in human microglia by type I and II interferons. / McManus, Carrie M.; Liu, Judy S H; Hahn, Matthew T.; Hua, Liwei L.; Brosnan, Celia F.; Berman, Joan W.; Lee, Sunhee C.

In: GLIA, Vol. 29, No. 3, 01.02.2000, p. 273-280.

Research output: Contribution to journalArticle

McManus, Carrie M. ; Liu, Judy S H ; Hahn, Matthew T. ; Hua, Liwei L. ; Brosnan, Celia F. ; Berman, Joan W. ; Lee, Sunhee C. / Differential induction of chemokines in human microglia by type I and II interferons. In: GLIA. 2000 ; Vol. 29, No. 3. pp. 273-280.
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