Differential expression of surface markers on thymic lymphomas induced by two carcinogenic agents in different mouse strains

L. E. Diamond, J. W. Berman, A. Pellicer

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Expression of several thymocyte surface antigens was monitored in a murine model system of thymic lymphoma induction in two different strains of mice. RF/J mice are sensitive to tumor induction by N-nitrosomethylurea (NMU) and by γ-irradiation, while 129/J mice form tumors only upon NMU treatment. Latency periods for tumor formation were characteristically different depending upon the inducing agent and the mouse strain. We observed differences in thymic leukemia antigen and H-2K expression according to the mode of tumor induction and in relation to the mouse strain, implying multiple factors involved in target cell selection and tumor progression.

Original languageEnglish (US)
Pages (from-to)115-120
Number of pages6
JournalCellular Immunology
Volume107
Issue number1
DOIs
StatePublished - Jun 1987
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology