Differential expression of surface markers on thymic lymphomas induced by two carcinogenic agents in different mouse strains

L. E. Diamond; J. W. Berman; A. Pellicer

doi:10.1016/0008-8749(87)90271-1

Differential expression of surface markers on thymic lymphomas induced by two carcinogenic agents in different mouse strains

L. E. Diamond, J. W. Berman, A. Pellicer

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Expression of several thymocyte surface antigens was monitored in a murine model system of thymic lymphoma induction in two different strains of mice. RF/J mice are sensitive to tumor induction by N-nitrosomethylurea (NMU) and by γ-irradiation, while 129/J mice form tumors only upon NMU treatment. Latency periods for tumor formation were characteristically different depending upon the inducing agent and the mouse strain. We observed differences in thymic leukemia antigen and H-2K expression according to the mode of tumor induction and in relation to the mouse strain, implying multiple factors involved in target cell selection and tumor progression.

Original language	English (US)
Pages (from-to)	115-120
Number of pages	6
Journal	Cellular Immunology
Volume	107
Issue number	1
DOIs	https://doi.org/10.1016/0008-8749(87)90271-1
State	Published - Jun 1987
Externally published	Yes

ASJC Scopus subject areas

Immunology

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10.1016/0008-8749(87)90271-1

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@article{4d224b1addbc48b784302e1fa60b6e24,

title = "Differential expression of surface markers on thymic lymphomas induced by two carcinogenic agents in different mouse strains",

abstract = "Expression of several thymocyte surface antigens was monitored in a murine model system of thymic lymphoma induction in two different strains of mice. RF/J mice are sensitive to tumor induction by N-nitrosomethylurea (NMU) and by γ-irradiation, while 129/J mice form tumors only upon NMU treatment. Latency periods for tumor formation were characteristically different depending upon the inducing agent and the mouse strain. We observed differences in thymic leukemia antigen and H-2K expression according to the mode of tumor induction and in relation to the mouse strain, implying multiple factors involved in target cell selection and tumor progression.",

author = "Diamond, {L. E.} and Berman, {J. W.} and A. Pellicer",

note = "Funding Information: {\textquoteright} This work was supported by NIH Grant POlA123276 and NIEHS Grant ES03847. * Present address: Department of Pathology, Albert Einstein College of Medicine, F-538, 1300 Morris Park Ave., Bronx, NY 10461 . 3 Abbreviations used: TL, thymic leukemia antigen; NMU, n-nitroso-n-methylurea; PBS, phosphate-buffered saline; BSA, bovine serum albumin; NaAzide; sodium azide; FITC, fluorescein-isothiocyanate; MCA, 3-methylcholanthrene.",

year = "1987",

month = jun,

doi = "10.1016/0008-8749(87)90271-1",

language = "English (US)",

volume = "107",

pages = "115--120",

journal = "Cellular Immunology",

issn = "0008-8749",

publisher = "Academic Press Inc.",

number = "1",

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TY - JOUR

T1 - Differential expression of surface markers on thymic lymphomas induced by two carcinogenic agents in different mouse strains

AU - Diamond, L. E.

AU - Berman, J. W.

AU - Pellicer, A.

N1 - Funding Information: ’ This work was supported by NIH Grant POlA123276 and NIEHS Grant ES03847. * Present address: Department of Pathology, Albert Einstein College of Medicine, F-538, 1300 Morris Park Ave., Bronx, NY 10461 . 3 Abbreviations used: TL, thymic leukemia antigen; NMU, n-nitroso-n-methylurea; PBS, phosphate-buffered saline; BSA, bovine serum albumin; NaAzide; sodium azide; FITC, fluorescein-isothiocyanate; MCA, 3-methylcholanthrene.

PY - 1987/6

Y1 - 1987/6

N2 - Expression of several thymocyte surface antigens was monitored in a murine model system of thymic lymphoma induction in two different strains of mice. RF/J mice are sensitive to tumor induction by N-nitrosomethylurea (NMU) and by γ-irradiation, while 129/J mice form tumors only upon NMU treatment. Latency periods for tumor formation were characteristically different depending upon the inducing agent and the mouse strain. We observed differences in thymic leukemia antigen and H-2K expression according to the mode of tumor induction and in relation to the mouse strain, implying multiple factors involved in target cell selection and tumor progression.

AB - Expression of several thymocyte surface antigens was monitored in a murine model system of thymic lymphoma induction in two different strains of mice. RF/J mice are sensitive to tumor induction by N-nitrosomethylurea (NMU) and by γ-irradiation, while 129/J mice form tumors only upon NMU treatment. Latency periods for tumor formation were characteristically different depending upon the inducing agent and the mouse strain. We observed differences in thymic leukemia antigen and H-2K expression according to the mode of tumor induction and in relation to the mouse strain, implying multiple factors involved in target cell selection and tumor progression.

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JO - Cellular Immunology

JF - Cellular Immunology

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Differential expression of surface markers on thymic lymphomas induced by two carcinogenic agents in different mouse strains

Abstract

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