Differential expression of low molecular weight form of G_s-α in neostriatum and cerebellum: correlation with expression of calmodulin-independent adenylyl cyclase

Adenylyl cyclase of neostriatal plasma membranes is far less responsive to stimulation by Ca²⁺/calmodulin than is the enzyme from cerebellum. When these tissues were investigated with antibodies against known G-proteins, no difference could be detected in any G-protein species, other than G_s. Whereas the cerebellum expressed predominantly the large form of G_s-α, the neostriatum expressed mainly lower molecular weight forms. The possibility is considered that there is selective association between lower molecular weight forms of G_s and calmodulin-independent forms of adenylyl cyclase.