Differential expression of low molecular weight form of Gs-α in neostriatum and cerebellum: correlation with expression of calmodulin-independent adenylyl cyclase

Dermot M.F. Cooper, Christine L. Boyajian, Paul K. Goldsmith, Cecilia G. Unson, Allen Spiegel

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Adenylyl cyclase of neostriatal plasma membranes is far less responsive to stimulation by Ca2+/calmodulin than is the enzyme from cerebellum. When these tissues were investigated with antibodies against known G-proteins, no difference could be detected in any G-protein species, other than Gs. Whereas the cerebellum expressed predominantly the large form of Gs-α, the neostriatum expressed mainly lower molecular weight forms. The possibility is considered that there is selective association between lower molecular weight forms of Gs and calmodulin-independent forms of adenylyl cyclase.

Original languageEnglish (US)
Pages (from-to)143-146
Number of pages4
JournalBrain research
Volume523
Issue number1
DOIs
StatePublished - Jul 16 1990
Externally publishedYes

Keywords

  • Adenylyl cyclase
  • Calcium ion
  • Calmodulin
  • Caudate-putamen
  • Cerebellum
  • G-protein
  • Neostriatum
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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