Differential expression of low molecular weight form of Gs-α in neostriatum and cerebellum

correlation with expression of calmodulin-independent adenylyl cyclase

Dermot M F Cooper, Christine L. Boyajian, Paul K. Goldsmith, Cecilia G. Unson, Allen M. Spiegel

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Adenylyl cyclase of neostriatal plasma membranes is far less responsive to stimulation by Ca2+/calmodulin than is the enzyme from cerebellum. When these tissues were investigated with antibodies against known G-proteins, no difference could be detected in any G-protein species, other than Gs. Whereas the cerebellum expressed predominantly the large form of Gs-α, the neostriatum expressed mainly lower molecular weight forms. The possibility is considered that there is selective association between lower molecular weight forms of Gs and calmodulin-independent forms of adenylyl cyclase.

Original languageEnglish (US)
Pages (from-to)143-146
Number of pages4
JournalBrain Research
Volume523
Issue number1
DOIs
StatePublished - Jul 16 1990
Externally publishedYes

Fingerprint

Neostriatum
Calmodulin
GTP-Binding Proteins
Adenylyl Cyclases
Cerebellum
Molecular Weight
Cell Membrane
Antibodies
Enzymes

Keywords

  • Adenylyl cyclase
  • Calcium ion
  • Calmodulin
  • Caudate-putamen
  • Cerebellum
  • G-protein
  • Neostriatum
  • Rat

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Differential expression of low molecular weight form of Gs-α in neostriatum and cerebellum : correlation with expression of calmodulin-independent adenylyl cyclase. / Cooper, Dermot M F; Boyajian, Christine L.; Goldsmith, Paul K.; Unson, Cecilia G.; Spiegel, Allen M.

In: Brain Research, Vol. 523, No. 1, 16.07.1990, p. 143-146.

Research output: Contribution to journalArticle

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