Differential effects of smoking on lung cancer mortality before and after household stove improvement in Xuanwei, China

K. M. Lee, R. S. Chapman, M. Shen, J. H. Lubin, D. T. Silverman, X. He, Howard D. Hosgood, B. E. Chen, P. Rajaraman, N. E. Caporaso, J. F. Fraumeni, A. Blair, Q. Lan

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: In Xuanwei County, Yunnan Province, China, lung cancer mortality rates in both males and females are among the highest in China. Methods: We evaluated differential effects of smoking on lung cancer mortality before and after household stove improvement with chimney to reduce exposure to smoky coal emissions in the unique cohort in Xuanwei, China. Effects of independent variables on lung cancer mortality were measured as hazard ratios and 95% confidence intervals using a multivariable Cox regression model that included separate time-dependent variables for smoking duration (years) before and after stove improvement.Results and conclusion:We found that the effect of smoking on lung cancer risk becomes considerably stronger after chimney installation and consequent reduction of indoor coal smoke exposure.

Original languageEnglish (US)
Pages (from-to)727-729
Number of pages3
JournalBritish Journal of Cancer
Volume103
Issue number5
DOIs
StatePublished - Aug 2010
Externally publishedYes

Fingerprint

China
Lung Neoplasms
Smoking
Mortality
Coal
Proportional Hazards Models
Smoke
Confidence Intervals

Keywords

  • lung cancer
  • mortality
  • smoking
  • smoky coal
  • time-dependent variable
  • Xuanwei cohort

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Differential effects of smoking on lung cancer mortality before and after household stove improvement in Xuanwei, China. / Lee, K. M.; Chapman, R. S.; Shen, M.; Lubin, J. H.; Silverman, D. T.; He, X.; Hosgood, Howard D.; Chen, B. E.; Rajaraman, P.; Caporaso, N. E.; Fraumeni, J. F.; Blair, A.; Lan, Q.

In: British Journal of Cancer, Vol. 103, No. 5, 08.2010, p. 727-729.

Research output: Contribution to journalArticle

Lee, KM, Chapman, RS, Shen, M, Lubin, JH, Silverman, DT, He, X, Hosgood, HD, Chen, BE, Rajaraman, P, Caporaso, NE, Fraumeni, JF, Blair, A & Lan, Q 2010, 'Differential effects of smoking on lung cancer mortality before and after household stove improvement in Xuanwei, China', British Journal of Cancer, vol. 103, no. 5, pp. 727-729. https://doi.org/10.1038/sj.bjc.6605791
Lee, K. M. ; Chapman, R. S. ; Shen, M. ; Lubin, J. H. ; Silverman, D. T. ; He, X. ; Hosgood, Howard D. ; Chen, B. E. ; Rajaraman, P. ; Caporaso, N. E. ; Fraumeni, J. F. ; Blair, A. ; Lan, Q. / Differential effects of smoking on lung cancer mortality before and after household stove improvement in Xuanwei, China. In: British Journal of Cancer. 2010 ; Vol. 103, No. 5. pp. 727-729.
@article{40e7c3fa20a44a66a5e46e19094ca904,
title = "Differential effects of smoking on lung cancer mortality before and after household stove improvement in Xuanwei, China",
abstract = "Background: In Xuanwei County, Yunnan Province, China, lung cancer mortality rates in both males and females are among the highest in China. Methods: We evaluated differential effects of smoking on lung cancer mortality before and after household stove improvement with chimney to reduce exposure to smoky coal emissions in the unique cohort in Xuanwei, China. Effects of independent variables on lung cancer mortality were measured as hazard ratios and 95{\%} confidence intervals using a multivariable Cox regression model that included separate time-dependent variables for smoking duration (years) before and after stove improvement.Results and conclusion:We found that the effect of smoking on lung cancer risk becomes considerably stronger after chimney installation and consequent reduction of indoor coal smoke exposure.",
keywords = "lung cancer, mortality, smoking, smoky coal, time-dependent variable, Xuanwei cohort",
author = "Lee, {K. M.} and Chapman, {R. S.} and M. Shen and Lubin, {J. H.} and Silverman, {D. T.} and X. He and Hosgood, {Howard D.} and Chen, {B. E.} and P. Rajaraman and Caporaso, {N. E.} and Fraumeni, {J. F.} and A. Blair and Q. Lan",
year = "2010",
month = "8",
doi = "10.1038/sj.bjc.6605791",
language = "English (US)",
volume = "103",
pages = "727--729",
journal = "British Journal of Cancer",
issn = "0007-0920",
publisher = "Nature Publishing Group",
number = "5",

}

TY - JOUR

T1 - Differential effects of smoking on lung cancer mortality before and after household stove improvement in Xuanwei, China

AU - Lee, K. M.

AU - Chapman, R. S.

AU - Shen, M.

AU - Lubin, J. H.

AU - Silverman, D. T.

AU - He, X.

AU - Hosgood, Howard D.

AU - Chen, B. E.

AU - Rajaraman, P.

AU - Caporaso, N. E.

AU - Fraumeni, J. F.

AU - Blair, A.

AU - Lan, Q.

PY - 2010/8

Y1 - 2010/8

N2 - Background: In Xuanwei County, Yunnan Province, China, lung cancer mortality rates in both males and females are among the highest in China. Methods: We evaluated differential effects of smoking on lung cancer mortality before and after household stove improvement with chimney to reduce exposure to smoky coal emissions in the unique cohort in Xuanwei, China. Effects of independent variables on lung cancer mortality were measured as hazard ratios and 95% confidence intervals using a multivariable Cox regression model that included separate time-dependent variables for smoking duration (years) before and after stove improvement.Results and conclusion:We found that the effect of smoking on lung cancer risk becomes considerably stronger after chimney installation and consequent reduction of indoor coal smoke exposure.

AB - Background: In Xuanwei County, Yunnan Province, China, lung cancer mortality rates in both males and females are among the highest in China. Methods: We evaluated differential effects of smoking on lung cancer mortality before and after household stove improvement with chimney to reduce exposure to smoky coal emissions in the unique cohort in Xuanwei, China. Effects of independent variables on lung cancer mortality were measured as hazard ratios and 95% confidence intervals using a multivariable Cox regression model that included separate time-dependent variables for smoking duration (years) before and after stove improvement.Results and conclusion:We found that the effect of smoking on lung cancer risk becomes considerably stronger after chimney installation and consequent reduction of indoor coal smoke exposure.

KW - lung cancer

KW - mortality

KW - smoking

KW - smoky coal

KW - time-dependent variable

KW - Xuanwei cohort

UR - http://www.scopus.com/inward/record.url?scp=77955981192&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955981192&partnerID=8YFLogxK

U2 - 10.1038/sj.bjc.6605791

DO - 10.1038/sj.bjc.6605791

M3 - Article

VL - 103

SP - 727

EP - 729

JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 0007-0920

IS - 5

ER -