Differential effects of low-carbohydrate and low-fat diets on inflammation and endothelial function in diabetes

Nichola J. Davis, Jill P. Crandall, Srikanth Gajavelli, Joan W. Berman, Nora Tomuta, Judith Wylie-Rosett, Stuart D. Katz

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Objective: To characterize acute (postprandial) and chronic (after a 6-month period of weight loss) effects of a low-carbohydrate vs. a low-fat diet on subclinical markers of cardiovascular disease (CVD) in adults with type 2 diabetes. Design: At baseline and 6 months, measures of C-reactive protein (CRP), interleukin-6 (IL-6), soluble intercellular adhesion molecule (sICAM) and soluble E-selectin were obtained from archived samples (n=51) of participants randomized in a clinical trial comparing a low-carbohydrate and a low-fat diet. In a subset of participants (n=27), postprandial measures of these markers were obtained 3 h after a low-carbohydrate or low-fat liquid meal. Endothelial function was also measured by reactive hyperemic peripheral arterial tonometry during the meal test. Paired t tests and unpaired t tests compared within- and between-group changes. Results: There were no significant differences observed in postprandial measures of inflammation or endothelial function. After 6 months, CRP (mean±S.E.) decreased in the low-fat arm from 4.0±0.77 to 3.0±0.77 (P=.01). In the low-carbohydrate arm, sICAM decreased from 234±22 to 199±23 (P=.001), and soluble E-selectin decreased from 93±10 to 82±10 (P=.05.) A significant correlation between change in high-density lipoprotein and change in soluble E-selectin (r=-0.33, P=.04) and with the change in ICAM (r=-0.43, P=.01) was observed. Conclusions: Low-carbohydrate and low-fat diets both have beneficial effects on CVD markers. There may be different mechanisms through which weight loss with these diets potentially reduces CVD risk.

Original languageEnglish (US)
Pages (from-to)371-376
Number of pages6
JournalJournal of Diabetes and its Complications
Volume25
Issue number6
DOIs
StatePublished - Nov 2011

Fingerprint

Fat-Restricted Diet
Carbohydrates
E-Selectin
Inflammation
Cardiovascular Diseases
Cell Adhesion Molecules
C-Reactive Protein
Meals
Fats
Reducing Diet
Manometry
HDL Lipoproteins
Type 2 Diabetes Mellitus
Weight Loss
Interleukin-6
Clinical Trials

Keywords

  • Diet
  • Endothelial function
  • Inflammation
  • Type 2 diabetes

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Differential effects of low-carbohydrate and low-fat diets on inflammation and endothelial function in diabetes. / Davis, Nichola J.; Crandall, Jill P.; Gajavelli, Srikanth; Berman, Joan W.; Tomuta, Nora; Wylie-Rosett, Judith; Katz, Stuart D.

In: Journal of Diabetes and its Complications, Vol. 25, No. 6, 11.2011, p. 371-376.

Research output: Contribution to journalArticle

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AU - Tomuta, Nora

AU - Wylie-Rosett, Judith

AU - Katz, Stuart D.

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