TY - JOUR
T1 - Differential antigen specificity of hepatitis C virus-specific interleukin 17- and interferon γ-producing CD8 + T cells during chronic infection
AU - Grafmueller, Stefanie
AU - Billerbeck, Eva
AU - Blum, Hubert E.
AU - Neumann-Haefelin, Christoph
AU - Thimme, Robert
N1 - Funding Information:
Financial support. This work was supported by the Deutsche For-schungsgemeinschaft (Heisenberg Professorship TH-719/3-1 to R. T. and SFB 620). Potential conflicts of interest. All authors: No reported conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.
PY - 2012/4/1
Y1 - 2012/4/1
N2 - A subset of CD8 + T cells can secrete interleukin 17 (IL-17). However, very little information is currently available about their antigen specificity, tissue distribution, and biological relevance in chronic human viral infection. To address these issues, we comprehensively analyzed peripheral and intrahepatic CD8 + T-cell responses in a cohort of patients with chronic hepatitis C virus (HCV) infection for the antigen-specific production of IL-17 and interferon (IFN) γ. We found that HCV-specific IL-17-producing and retinoic acid receptor related orphan receptorγt-expressing CD8 + T cells are detectable in blood and liver and target different epitopes, compared with IFN-γ-producing CD8 + T cells. Their highest frequency was found in patients with low inflammatory activity, suggesting a protective role in chronic HCV infection.
AB - A subset of CD8 + T cells can secrete interleukin 17 (IL-17). However, very little information is currently available about their antigen specificity, tissue distribution, and biological relevance in chronic human viral infection. To address these issues, we comprehensively analyzed peripheral and intrahepatic CD8 + T-cell responses in a cohort of patients with chronic hepatitis C virus (HCV) infection for the antigen-specific production of IL-17 and interferon (IFN) γ. We found that HCV-specific IL-17-producing and retinoic acid receptor related orphan receptorγt-expressing CD8 + T cells are detectable in blood and liver and target different epitopes, compared with IFN-γ-producing CD8 + T cells. Their highest frequency was found in patients with low inflammatory activity, suggesting a protective role in chronic HCV infection.
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U2 - 10.1093/infdis/jis018
DO - 10.1093/infdis/jis018
M3 - Article
C2 - 22351943
AN - SCOPUS:84858175439
SN - 0022-1899
VL - 205
SP - 1142
EP - 1146
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 7
ER -
