Differential age effects of mean arterial pressure and rewarming on cognitive dysfunction after cardiac surgery

M. F. Newman, David C. Kramer, N. D. Croughwell, I. Sanderson, J. A. Blumenthal, W. D. White, L. R. Smith, E. A. Towner, J. G. Reves

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

Central nervous system dysfunction is a common consequence of otherwise uncomplicated cardiac surgery. Many mechanisms have been postulated for the cognitive dysfunction that is part of these neurologic sequelae. The purpose of our investigation was to evaluate the effects of mean arterial pressure (MAP) during cardiopulmonary bypass (CPB) and the rate of rewarming on cognitive decline after cardiac surgery. Two hundred thirty seven patients completed preoperative and predischarge neuropsychologic testing. MAP and temperature were recorded at 1-min intervals using an automated anesthesia record keeper. MAP area less than 50 mm Hg (time and degree of hypotension), as well as the maximal rewarming rate, were determined for each patient. Multivariable linear regression revealed that the rate of rewarming and MAP were unrelated to cognitive decline. However, interactions significantly associated with cognitive decline were found between age and MAP area less than 50 mm Hg on one measure, and between age and rewarming rate in another, identifying susceptibility of the elderly to these factors. Although MAP and rewarming were not the primary determinates of cognitive decline in this surgical population, hypotension and rapid rewarming contributed significantly to cognitive dysfunction in the elderly.

Original languageEnglish (US)
Pages (from-to)236-242
Number of pages7
JournalAnesthesia and Analgesia
Volume81
Issue number2
DOIs
StatePublished - Aug 11 1995
Externally publishedYes

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Rewarming
Thoracic Surgery
Arterial Pressure
Hypotension
Cardiopulmonary Bypass
Nervous System
Cognitive Dysfunction
Linear Models
Anesthesia
Central Nervous System
Temperature
Population

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Differential age effects of mean arterial pressure and rewarming on cognitive dysfunction after cardiac surgery. / Newman, M. F.; Kramer, David C.; Croughwell, N. D.; Sanderson, I.; Blumenthal, J. A.; White, W. D.; Smith, L. R.; Towner, E. A.; Reves, J. G.

In: Anesthesia and Analgesia, Vol. 81, No. 2, 11.08.1995, p. 236-242.

Research output: Contribution to journalArticle

Newman, MF, Kramer, DC, Croughwell, ND, Sanderson, I, Blumenthal, JA, White, WD, Smith, LR, Towner, EA & Reves, JG 1995, 'Differential age effects of mean arterial pressure and rewarming on cognitive dysfunction after cardiac surgery', Anesthesia and Analgesia, vol. 81, no. 2, pp. 236-242. https://doi.org/10.1097/00000539-199508000-00005
Newman, M. F. ; Kramer, David C. ; Croughwell, N. D. ; Sanderson, I. ; Blumenthal, J. A. ; White, W. D. ; Smith, L. R. ; Towner, E. A. ; Reves, J. G. / Differential age effects of mean arterial pressure and rewarming on cognitive dysfunction after cardiac surgery. In: Anesthesia and Analgesia. 1995 ; Vol. 81, No. 2. pp. 236-242.
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