Different sequence environments of cysteines and half cystines in proteins Application to predict disulfide forming residues

András Fiser; Miklós Cserzö; Éva Tüdös; István Simon

doi:10.1016/0014-5793(92)80419-H

Different sequence environments of cysteines and half cystines in proteins Application to predict disulfide forming residues

András Fiser, Miklós Cserzö, Éva Tüdös, István Simon

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Protein sequences are often derived by translating genetic information, rather than by classical protein sequencing. At the DNA level cysteines and half cystines are indistinguishable. Here we show that the sequential environments of 'free' cysteine and half cystine are different. A possible origin of this difference is discussed and a simple method to predict cysteines and half cystines from the amino acid sequence is also presented.

Original language	English (US)
Pages (from-to)	117-120
Number of pages	4
Journal	FEBS Letters
Volume	302
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(92)80419-H
State	Published - May 11 1992
Externally published	Yes

Keywords

Free cysteine
Half cystine
Prediction
Sequential environment

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/0014-5793(92)80419-H

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T1 - Different sequence environments of cysteines and half cystines in proteins Application to predict disulfide forming residues

AU - Fiser, András

AU - Cserzö, Miklós

AU - Tüdös, Éva

AU - Simon, István

PY - 1992/5/11

Y1 - 1992/5/11

N2 - Protein sequences are often derived by translating genetic information, rather than by classical protein sequencing. At the DNA level cysteines and half cystines are indistinguishable. Here we show that the sequential environments of 'free' cysteine and half cystine are different. A possible origin of this difference is discussed and a simple method to predict cysteines and half cystines from the amino acid sequence is also presented.

AB - Protein sequences are often derived by translating genetic information, rather than by classical protein sequencing. At the DNA level cysteines and half cystines are indistinguishable. Here we show that the sequential environments of 'free' cysteine and half cystine are different. A possible origin of this difference is discussed and a simple method to predict cysteines and half cystines from the amino acid sequence is also presented.

KW - Free cysteine

KW - Half cystine

KW - Prediction

KW - Sequential environment

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ER -

Different sequence environments of cysteines and half cystines in proteins Application to predict disulfide forming residues

Abstract

Keywords

ASJC Scopus subject areas

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