Different sequence environments of cysteines and half cystines in proteins Application to predict disulfide forming residues

Andras Fiser, Miklós Cserzö, Éva Tüdös, István Simon

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Protein sequences are often derived by translating genetic information, rather than by classical protein sequencing. At the DNA level cysteines and half cystines are indistinguishable. Here we show that the sequential environments of 'free' cysteine and half cystine are different. A possible origin of this difference is discussed and a simple method to predict cysteines and half cystines from the amino acid sequence is also presented.

Original languageEnglish (US)
Pages (from-to)117-120
Number of pages4
JournalFEBS Letters
Volume302
Issue number2
DOIs
StatePublished - May 11 1992
Externally publishedYes

Fingerprint

Disulfides
Cysteine
Proteins
Protein Sequence Analysis
Amino Acid Sequence
Amino Acids
DNA

Keywords

  • Free cysteine
  • Half cystine
  • Prediction
  • Sequential environment

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Different sequence environments of cysteines and half cystines in proteins Application to predict disulfide forming residues. / Fiser, Andras; Cserzö, Miklós; Tüdös, Éva; Simon, István.

In: FEBS Letters, Vol. 302, No. 2, 11.05.1992, p. 117-120.

Research output: Contribution to journalArticle

Fiser, Andras ; Cserzö, Miklós ; Tüdös, Éva ; Simon, István. / Different sequence environments of cysteines and half cystines in proteins Application to predict disulfide forming residues. In: FEBS Letters. 1992 ; Vol. 302, No. 2. pp. 117-120.
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