Differences in susceptibility to herpes simplex virus infection of inbred strains of mice.

H. Kirchner; M. Kochen; K. Munk; H. M. Hirt; S. E. Mergenhagen; D. L. Rosenstreich

Differences in susceptibility to herpes simplex virus infection of inbred strains of mice.

H. Kirchner, M. Kochen, K. Munk, H. M. Hirt, S. E. Mergenhagen, D. L. Rosenstreich

Research output: Contribution to journal › Article › peer-review

Abstract

Marked differences were observed between the susceptibility of adult C57BL/6 and DBA/2 mice to infection with HSV-1. These differences were seen after various infection schedules but were most marked after i.p. infection. A significant difference between the LD50 after i.p. infection was also observed between LPS-resistant C3H/HeJ and the closely related LPS-sensitive C3HeB/FeJ mice. Injection of LPS significantly increased the LD50 after i.p. infection with HSV in C57BL/6 or C3H/HeJ mice but not in C3HeB/FeJ mice. In vitro pretreatment with LPS was necessary to demonstrate replication of HSV in mouse spleen-cell cultures. Such replication could be demonstrated in cultures of DBA/2 and C3HeB/FeJ but not in C57BL/6 or C3H/HeJ mice.

Original language	English (US)
Pages (from-to)	783-788
Number of pages	6
Journal	IARC scientific publications
Issue number	24 Pt 2
State	Published - 1978
Externally published	Yes

ASJC Scopus subject areas

General Medicine

Cite this

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title = "Differences in susceptibility to herpes simplex virus infection of inbred strains of mice.",

abstract = "Marked differences were observed between the susceptibility of adult C57BL/6 and DBA/2 mice to infection with HSV-1. These differences were seen after various infection schedules but were most marked after i.p. infection. A significant difference between the LD50 after i.p. infection was also observed between LPS-resistant C3H/HeJ and the closely related LPS-sensitive C3HeB/FeJ mice. Injection of LPS significantly increased the LD50 after i.p. infection with HSV in C57BL/6 or C3H/HeJ mice but not in C3HeB/FeJ mice. In vitro pretreatment with LPS was necessary to demonstrate replication of HSV in mouse spleen-cell cultures. Such replication could be demonstrated in cultures of DBA/2 and C3HeB/FeJ but not in C57BL/6 or C3H/HeJ mice.",

author = "H. Kirchner and M. Kochen and K. Munk and Hirt, {H. M.} and Mergenhagen, {S. E.} and Rosenstreich, {D. L.}",

year = "1978",

language = "English (US)",

pages = "783--788",

journal = "IARC scientific publications",

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publisher = "IARC",

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T1 - Differences in susceptibility to herpes simplex virus infection of inbred strains of mice.

AU - Kirchner, H.

AU - Kochen, M.

AU - Munk, K.

AU - Hirt, H. M.

AU - Mergenhagen, S. E.

AU - Rosenstreich, D. L.

PY - 1978

Y1 - 1978

N2 - Marked differences were observed between the susceptibility of adult C57BL/6 and DBA/2 mice to infection with HSV-1. These differences were seen after various infection schedules but were most marked after i.p. infection. A significant difference between the LD50 after i.p. infection was also observed between LPS-resistant C3H/HeJ and the closely related LPS-sensitive C3HeB/FeJ mice. Injection of LPS significantly increased the LD50 after i.p. infection with HSV in C57BL/6 or C3H/HeJ mice but not in C3HeB/FeJ mice. In vitro pretreatment with LPS was necessary to demonstrate replication of HSV in mouse spleen-cell cultures. Such replication could be demonstrated in cultures of DBA/2 and C3HeB/FeJ but not in C57BL/6 or C3H/HeJ mice.

AB - Marked differences were observed between the susceptibility of adult C57BL/6 and DBA/2 mice to infection with HSV-1. These differences were seen after various infection schedules but were most marked after i.p. infection. A significant difference between the LD50 after i.p. infection was also observed between LPS-resistant C3H/HeJ and the closely related LPS-sensitive C3HeB/FeJ mice. Injection of LPS significantly increased the LD50 after i.p. infection with HSV in C57BL/6 or C3H/HeJ mice but not in C3HeB/FeJ mice. In vitro pretreatment with LPS was necessary to demonstrate replication of HSV in mouse spleen-cell cultures. Such replication could be demonstrated in cultures of DBA/2 and C3HeB/FeJ but not in C57BL/6 or C3H/HeJ mice.

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JO - IARC scientific publications

JF - IARC scientific publications

IS - 24 Pt 2

ER -

Differences in susceptibility to herpes simplex virus infection of inbred strains of mice.

Abstract

ASJC Scopus subject areas

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