Differences in susceptibility to herpes simplex virus infection of inbred strains of mice.

H. Kirchner, M. Kochen, K. Munk, H. M. Hirt, S. E. Mergenhagen, David L. Rosenstreich

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Marked differences were observed between the susceptibility of adult C57BL/6 and DBA/2 mice to infection with HSV-1. These differences were seen after various infection schedules but were most marked after i.p. infection. A significant difference between the LD50 after i.p. infection was also observed between LPS-resistant C3H/HeJ and the closely related LPS-sensitive C3HeB/FeJ mice. Injection of LPS significantly increased the LD50 after i.p. infection with HSV in C57BL/6 or C3H/HeJ mice but not in C3HeB/FeJ mice. In vitro pretreatment with LPS was necessary to demonstrate replication of HSV in mouse spleen-cell cultures. Such replication could be demonstrated in cultures of DBA/2 and C3HeB/FeJ but not in C57BL/6 or C3H/HeJ mice.

Original languageEnglish (US)
Pages (from-to)783-788
Number of pages6
JournalIARC scientific publications
Issue number24 Pt 2
StatePublished - 1978
Externally publishedYes

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Inbred Strains Mice
Virus Diseases
Simplexvirus
Infection
Inbred C3H Mouse
Lethal Dose 50
Inbred DBA Mouse
Human Herpesvirus 1
Appointments and Schedules
Spleen
Cell Culture Techniques
Injections

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kirchner, H., Kochen, M., Munk, K., Hirt, H. M., Mergenhagen, S. E., & Rosenstreich, D. L. (1978). Differences in susceptibility to herpes simplex virus infection of inbred strains of mice. IARC scientific publications, (24 Pt 2), 783-788.

Differences in susceptibility to herpes simplex virus infection of inbred strains of mice. / Kirchner, H.; Kochen, M.; Munk, K.; Hirt, H. M.; Mergenhagen, S. E.; Rosenstreich, David L.

In: IARC scientific publications, No. 24 Pt 2, 1978, p. 783-788.

Research output: Contribution to journalArticle

Kirchner, H, Kochen, M, Munk, K, Hirt, HM, Mergenhagen, SE & Rosenstreich, DL 1978, 'Differences in susceptibility to herpes simplex virus infection of inbred strains of mice.', IARC scientific publications, no. 24 Pt 2, pp. 783-788.
Kirchner, H. ; Kochen, M. ; Munk, K. ; Hirt, H. M. ; Mergenhagen, S. E. ; Rosenstreich, David L. / Differences in susceptibility to herpes simplex virus infection of inbred strains of mice. In: IARC scientific publications. 1978 ; No. 24 Pt 2. pp. 783-788.
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