Differences in active and passive smoking exposures and lung cancer incidence between veterans and non-veterans in the Women' S Health Initiative

Lori A. Bastian, Kristen E. Gray, Eric Derycke, Shireen Mirza, Jennifer M. Gierisch, Sally G. Haskell, Kathryn M. Magruder, Heather A. Wakelee, Ange Wang, Gloria Y F Ho, Andrea Z. Lacroix

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Introduction: Women Veterans may have higher rates of both active and passive tobacco exposure than their civilian counterparts, thereby increasing their risk for lung cancer. Purpose of the Study: To compare differences in active and passive smoking exposure and lung cancer incidence among women Veterans and non-Veterans using prospective data from the Women' s Health Initiative (WHI). Design and Methods: We used data from the WHI, which collected longitudinal demographic, clinical, and laboratory data on 161,808 postmenopausal women. We employed linear and multinomial regression and generalized linear models to compare active and passive smoking exposure between Veterans and non-Veterans and Cox proportional hazards models to estimate differences in lung cancer incidence rates. Results: After adjustment, Veterans had 2.54 additional pack years of smoking compared with non-Veterans (95% confidence interval [CI] 1.68, 3.40). Veterans also had a 1% increase in risk of any passive smoking exposure (95% CI 1.00, 1.02) and a 9% increase in risk of any workplace exposure (95% CI 1.07, 1.11) compared with non-Veterans. After adjustment for age and smoking exposures, Veterans did not have a higher risk of lung cancer compared with non-Veterans (relative risk = 1.06 95% CI 0.86, 1.30). Implications: Women Veterans had higher rates of tobacco use and exposure to passive smoking, which were associated with a higher risk for lung cancer compared with non-Veterans. Clinicians who care for Veterans need to be aware that older women Veterans have more exposures to risk factors for lung cancer.

Original languageEnglish (US)
Pages (from-to)S102-S111
JournalGerontologist
Volume56
DOIs
StatePublished - Feb 1 2016

Fingerprint

Tobacco Smoke Pollution
Women's Health
Veterans
Lung Neoplasms
Incidence
Confidence Intervals
Linear Models
Smoking
Social Adjustment
Tobacco Use
Proportional Hazards Models
Workplace
Tobacco
Demography

Keywords

  • Lung cancer
  • Smoking
  • Tobacco
  • Women Veterans

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Gerontology

Cite this

Bastian, L. A., Gray, K. E., Derycke, E., Mirza, S., Gierisch, J. M., Haskell, S. G., ... Lacroix, A. Z. (2016). Differences in active and passive smoking exposures and lung cancer incidence between veterans and non-veterans in the Women' S Health Initiative. Gerontologist, 56, S102-S111. https://doi.org/10.1093/geront/gnv664

Differences in active and passive smoking exposures and lung cancer incidence between veterans and non-veterans in the Women' S Health Initiative. / Bastian, Lori A.; Gray, Kristen E.; Derycke, Eric; Mirza, Shireen; Gierisch, Jennifer M.; Haskell, Sally G.; Magruder, Kathryn M.; Wakelee, Heather A.; Wang, Ange; Ho, Gloria Y F; Lacroix, Andrea Z.

In: Gerontologist, Vol. 56, 01.02.2016, p. S102-S111.

Research output: Contribution to journalArticle

Bastian, LA, Gray, KE, Derycke, E, Mirza, S, Gierisch, JM, Haskell, SG, Magruder, KM, Wakelee, HA, Wang, A, Ho, GYF & Lacroix, AZ 2016, 'Differences in active and passive smoking exposures and lung cancer incidence between veterans and non-veterans in the Women' S Health Initiative', Gerontologist, vol. 56, pp. S102-S111. https://doi.org/10.1093/geront/gnv664
Bastian, Lori A. ; Gray, Kristen E. ; Derycke, Eric ; Mirza, Shireen ; Gierisch, Jennifer M. ; Haskell, Sally G. ; Magruder, Kathryn M. ; Wakelee, Heather A. ; Wang, Ange ; Ho, Gloria Y F ; Lacroix, Andrea Z. / Differences in active and passive smoking exposures and lung cancer incidence between veterans and non-veterans in the Women' S Health Initiative. In: Gerontologist. 2016 ; Vol. 56. pp. S102-S111.
@article{7c832e808ae24010ab26aada129800cf,
title = "Differences in active and passive smoking exposures and lung cancer incidence between veterans and non-veterans in the Women' S Health Initiative",
abstract = "Introduction: Women Veterans may have higher rates of both active and passive tobacco exposure than their civilian counterparts, thereby increasing their risk for lung cancer. Purpose of the Study: To compare differences in active and passive smoking exposure and lung cancer incidence among women Veterans and non-Veterans using prospective data from the Women' s Health Initiative (WHI). Design and Methods: We used data from the WHI, which collected longitudinal demographic, clinical, and laboratory data on 161,808 postmenopausal women. We employed linear and multinomial regression and generalized linear models to compare active and passive smoking exposure between Veterans and non-Veterans and Cox proportional hazards models to estimate differences in lung cancer incidence rates. Results: After adjustment, Veterans had 2.54 additional pack years of smoking compared with non-Veterans (95{\%} confidence interval [CI] 1.68, 3.40). Veterans also had a 1{\%} increase in risk of any passive smoking exposure (95{\%} CI 1.00, 1.02) and a 9{\%} increase in risk of any workplace exposure (95{\%} CI 1.07, 1.11) compared with non-Veterans. After adjustment for age and smoking exposures, Veterans did not have a higher risk of lung cancer compared with non-Veterans (relative risk = 1.06 95{\%} CI 0.86, 1.30). Implications: Women Veterans had higher rates of tobacco use and exposure to passive smoking, which were associated with a higher risk for lung cancer compared with non-Veterans. Clinicians who care for Veterans need to be aware that older women Veterans have more exposures to risk factors for lung cancer.",
keywords = "Lung cancer, Smoking, Tobacco, Women Veterans",
author = "Bastian, {Lori A.} and Gray, {Kristen E.} and Eric Derycke and Shireen Mirza and Gierisch, {Jennifer M.} and Haskell, {Sally G.} and Magruder, {Kathryn M.} and Wakelee, {Heather A.} and Ange Wang and Ho, {Gloria Y F} and Lacroix, {Andrea Z.}",
year = "2016",
month = "2",
day = "1",
doi = "10.1093/geront/gnv664",
language = "English (US)",
volume = "56",
pages = "S102--S111",
journal = "The Gerontologist",
issn = "0016-9013",
publisher = "Oxford University Press",

}

TY - JOUR

T1 - Differences in active and passive smoking exposures and lung cancer incidence between veterans and non-veterans in the Women' S Health Initiative

AU - Bastian, Lori A.

AU - Gray, Kristen E.

AU - Derycke, Eric

AU - Mirza, Shireen

AU - Gierisch, Jennifer M.

AU - Haskell, Sally G.

AU - Magruder, Kathryn M.

AU - Wakelee, Heather A.

AU - Wang, Ange

AU - Ho, Gloria Y F

AU - Lacroix, Andrea Z.

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Introduction: Women Veterans may have higher rates of both active and passive tobacco exposure than their civilian counterparts, thereby increasing their risk for lung cancer. Purpose of the Study: To compare differences in active and passive smoking exposure and lung cancer incidence among women Veterans and non-Veterans using prospective data from the Women' s Health Initiative (WHI). Design and Methods: We used data from the WHI, which collected longitudinal demographic, clinical, and laboratory data on 161,808 postmenopausal women. We employed linear and multinomial regression and generalized linear models to compare active and passive smoking exposure between Veterans and non-Veterans and Cox proportional hazards models to estimate differences in lung cancer incidence rates. Results: After adjustment, Veterans had 2.54 additional pack years of smoking compared with non-Veterans (95% confidence interval [CI] 1.68, 3.40). Veterans also had a 1% increase in risk of any passive smoking exposure (95% CI 1.00, 1.02) and a 9% increase in risk of any workplace exposure (95% CI 1.07, 1.11) compared with non-Veterans. After adjustment for age and smoking exposures, Veterans did not have a higher risk of lung cancer compared with non-Veterans (relative risk = 1.06 95% CI 0.86, 1.30). Implications: Women Veterans had higher rates of tobacco use and exposure to passive smoking, which were associated with a higher risk for lung cancer compared with non-Veterans. Clinicians who care for Veterans need to be aware that older women Veterans have more exposures to risk factors for lung cancer.

AB - Introduction: Women Veterans may have higher rates of both active and passive tobacco exposure than their civilian counterparts, thereby increasing their risk for lung cancer. Purpose of the Study: To compare differences in active and passive smoking exposure and lung cancer incidence among women Veterans and non-Veterans using prospective data from the Women' s Health Initiative (WHI). Design and Methods: We used data from the WHI, which collected longitudinal demographic, clinical, and laboratory data on 161,808 postmenopausal women. We employed linear and multinomial regression and generalized linear models to compare active and passive smoking exposure between Veterans and non-Veterans and Cox proportional hazards models to estimate differences in lung cancer incidence rates. Results: After adjustment, Veterans had 2.54 additional pack years of smoking compared with non-Veterans (95% confidence interval [CI] 1.68, 3.40). Veterans also had a 1% increase in risk of any passive smoking exposure (95% CI 1.00, 1.02) and a 9% increase in risk of any workplace exposure (95% CI 1.07, 1.11) compared with non-Veterans. After adjustment for age and smoking exposures, Veterans did not have a higher risk of lung cancer compared with non-Veterans (relative risk = 1.06 95% CI 0.86, 1.30). Implications: Women Veterans had higher rates of tobacco use and exposure to passive smoking, which were associated with a higher risk for lung cancer compared with non-Veterans. Clinicians who care for Veterans need to be aware that older women Veterans have more exposures to risk factors for lung cancer.

KW - Lung cancer

KW - Smoking

KW - Tobacco

KW - Women Veterans

UR - http://www.scopus.com/inward/record.url?scp=84960954289&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84960954289&partnerID=8YFLogxK

U2 - 10.1093/geront/gnv664

DO - 10.1093/geront/gnv664

M3 - Article

VL - 56

SP - S102-S111

JO - The Gerontologist

JF - The Gerontologist

SN - 0016-9013

ER -