Differences between germline and somatic mutation rates in humans and mice

Brandon Milholland, Xiao Dong, Lei Zhang, Xiaoxiao Hao, Yousin Suh, Jan Vijg

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

The germline mutation rate has been extensively studied and has been found to vary greatly between species, but much less is known about the somatic mutation rate in multicellular organisms, which remains very difficult to determine. Here, we present data on somatic mutation rates in mice and humans, obtained by sequencing single cells and clones derived from primary fibroblasts, which allows us to make the first direct comparison with germline mutation rates in these two species. The results indicate that the somatic mutation rate is almost two orders of magnitude higher than the germline mutation rate and that both mutation rates are significantly higher in mice than in humans. Our findings demonstrate both the privileged status of germline genome integrity and species-specific differences in genome maintenance.

Original languageEnglish (US)
Article number15183
JournalNature Communications
Volume8
DOIs
StatePublished - May 9 2017

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Germ-Line Mutation
Mutation Rate
mutations
mice
Genes
Fibroblasts
genome
Genome
sequencing
fibroblasts
organisms
integrity
maintenance
Clone Cells
Maintenance
cells

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Differences between germline and somatic mutation rates in humans and mice. / Milholland, Brandon; Dong, Xiao; Zhang, Lei; Hao, Xiaoxiao; Suh, Yousin; Vijg, Jan.

In: Nature Communications, Vol. 8, 15183, 09.05.2017.

Research output: Contribution to journalArticle

Milholland, Brandon ; Dong, Xiao ; Zhang, Lei ; Hao, Xiaoxiao ; Suh, Yousin ; Vijg, Jan. / Differences between germline and somatic mutation rates in humans and mice. In: Nature Communications. 2017 ; Vol. 8.
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