Differences and similarities in the clinicopathological features of pancreatic neuroendocrine tumors in China and the United States

A multicenter study

Li Ming Zhu, Laura Tang, Xin Wei Qiao, Edward Wolin, Nicholas N. Nissen, Deepti Dhall, Jie Chen, Lin Shen, Yihebali Chi, Yao Zong Yuan, Qi Wen Ben, Bin Lv, Ya Ru Zhou, Chun Mei Bai, Jie Chen, Yu Li Song, Tian Tian Song, Chong Mei Lu, Run Yu, Yuan Jia Chen

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The presentation, pathology, and prognosis of pancreatic neuroendocrine tumors (PNETs) in Asian patients have not been studied in large cohorts. We hypothesized that the clinicopathological features of PNETs of Chinese patients might be different from those of US patients. The objectives of this study were to address whether PNETs in Chinese patients exhibit unique clinicopathological features and natural history, and can be graded and staged using the WHO/ENETS criteria. This is a retrospective review of medical records of patients with PNETs in multiple academic medical centers in China (7) and the United States (2). Tumor grading and staging were based on WHO/ENETS criteria. The clinicopathological features of PNETs of Chinese and US patients were compared. Univariate and multivariate analyses were performed to find associations between survival and patient demographics, tumor grade and stage, and other clinicopathological characteristics. A total of 977 (527 Chinese and 450 US) patients with PNETs were studied. In general, Chinese patients were younger than US patients (median age 46 vs 56 years). In Chinese patients, insulinomas were the most common (52.2%), followed by nonfunctional tumors (39.7%), whereas the order was reversed in US patients. Tumor grade distribution was similar in the 2 countries (G1: 57.5% vs 55.0%; G2: 38.5% vs 41.3%; and G3: 4.0% vs 3.7%). However, age, primary tumor size, primary tumor location, grade, and stage of subtypes of PNETs were significantly different between the 2 countries. The Chinese nonfunctional tumors were significantly larger than US ones (median size 4 vs 3 cm) and more frequently located in the head/neck region (54.9% vs 34.8%). The Chinese and US insulinomas were similar in size (median 1.5 cm) but the Chinese insulinomas relatively more frequently located in the head/neck region (48.3% vs 26.1%). Higher grade, advanced stage, metastasis, and larger primary tumor size were significantly associated with unfavorable survival in both countries. Several clinicopathological differences are found between Chinese and US PNETs but the PNETs of both countries follow a similar natural history. The WHO tumor grading and ENETS staging criteria are applicable to both Chinese and US patients.

Original languageEnglish (US)
Pages (from-to)e2836
JournalMedicine (United States)
Volume95
Issue number7
DOIs
StatePublished - 2016
Externally publishedYes

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Neuroendocrine Tumors
Multicenter Studies
China
Insulinoma
Neoplasms
Neoplasm Grading
Natural History
Neck
Head
Survival
Neoplasm Staging
Medical Records
Multivariate Analysis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Differences and similarities in the clinicopathological features of pancreatic neuroendocrine tumors in China and the United States : A multicenter study. / Zhu, Li Ming; Tang, Laura; Qiao, Xin Wei; Wolin, Edward; Nissen, Nicholas N.; Dhall, Deepti; Chen, Jie; Shen, Lin; Chi, Yihebali; Yuan, Yao Zong; Ben, Qi Wen; Lv, Bin; Zhou, Ya Ru; Bai, Chun Mei; Chen, Jie; Song, Yu Li; Song, Tian Tian; Lu, Chong Mei; Yu, Run; Chen, Yuan Jia.

In: Medicine (United States), Vol. 95, No. 7, 2016, p. e2836.

Research output: Contribution to journalArticle

Zhu, LM, Tang, L, Qiao, XW, Wolin, E, Nissen, NN, Dhall, D, Chen, J, Shen, L, Chi, Y, Yuan, YZ, Ben, QW, Lv, B, Zhou, YR, Bai, CM, Chen, J, Song, YL, Song, TT, Lu, CM, Yu, R & Chen, YJ 2016, 'Differences and similarities in the clinicopathological features of pancreatic neuroendocrine tumors in China and the United States: A multicenter study', Medicine (United States), vol. 95, no. 7, pp. e2836. https://doi.org/10.1097/MD.0000000000002836
Zhu, Li Ming ; Tang, Laura ; Qiao, Xin Wei ; Wolin, Edward ; Nissen, Nicholas N. ; Dhall, Deepti ; Chen, Jie ; Shen, Lin ; Chi, Yihebali ; Yuan, Yao Zong ; Ben, Qi Wen ; Lv, Bin ; Zhou, Ya Ru ; Bai, Chun Mei ; Chen, Jie ; Song, Yu Li ; Song, Tian Tian ; Lu, Chong Mei ; Yu, Run ; Chen, Yuan Jia. / Differences and similarities in the clinicopathological features of pancreatic neuroendocrine tumors in China and the United States : A multicenter study. In: Medicine (United States). 2016 ; Vol. 95, No. 7. pp. e2836.
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