Dietary lipids and aging compromise chaperone-mediated autophagy by similar mechanisms

Jose Antonio Rodriguez Navarro, Ana Maria Cuervo

Research output: Contribution to journalShort survey

14 Scopus citations

Abstract

Chaperone-mediated autophagy (CMA) is a selective form of autophagy whose distinctive feature is the fact that substrate proteins are translocated directly from the cytosol across the lysosomal membrane for degradation inside lysosomes. CMA substrates are cytosolic proteins bearing a pentapeptide motif in their sequence that, when recognized by the cytosolic chaperone HSPA8/HSC70, targets them to the surface of the lysosomes. Once there, substrate proteins bind to the lysosome-associated membrane protein type 2 isoform A (LAMP2A), inducing assembly of this receptor protein into a higher molecular weight protein complex that is used by the substrate proteins to reach the lysosomal lumen. CMA is constitutively active in most cells but it is maximally activated under conditions of stress.

Original languageEnglish (US)
Pages (from-to)1152-1154
Number of pages3
JournalAutophagy
Volume8
Issue number7
DOIs
StatePublished - Jul 2012

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Keywords

  • Cholesterol
  • Diet
  • Lipid microdomains
  • Lipidomic analysis
  • Lysosomes
  • Membrane proteins
  • Proteolysis

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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