Dietary fiber intake and risk of colorectal cancer

A pooled analysis of prospective cohort studies

Yikyung Park, David J. Hunter, Donna Spiegelman, Leif Bergkvist, Franco Berrino, Piet A. Van Den Brandt, Julie E. Buring, Graham A. Colditz, Jo L. Freudenheim, Charles S. Fuchs, Edward Giovannucci, R. Alexandra Goldbohm, Saxon Graham, Lisa Harnack, Anne M. Hartman, David R. Jacobs, Ikuko Kato, Vittorio Krogh, Michael F. Leitzmann, Marjorie L. McCullough & 9 others Anthony B. Miller, Pirjo Pietinen, Thomas E. Rohan, Arthur Schatzkin, Walter C. Willett, Alicja Wolk, Anne Zeleniuch-Jacquotte, Shumin M. Zhang, Stephanie A. Smith-Warner

Research output: Contribution to journalArticle

332 Citations (Scopus)

Abstract

Context: Inconsistent findings from observational studies have continued the controversy over the effects of dietary fiber on colorectal cancer. Objective: To evaluate the association between dietary fiber intake and risk of colorectal cancer. Design, Setting, and Participants: From 13 prospective cohort studies included in the Pooling Project of Prospective Studies of Diet and Cancer, 725 628 men and women were followed up for 6 to 20 years across studies. Study- and sex-specific relative risks (RRs) were estimated with the Cox proportional hazards model and were subsequently pooled using a random-effects model. Main Outcome Measure: Incident colorectal cancer. Results: During 6 to 20 years of follow-up across studies, 8081 colorectal cancer cases were identified. For comparison of the highest vs lowest study- and sex-specific quintile of dietary fiber intake, a significant inverse association was found in the age-adjusted model (pooled RR=0.84; 95% confidence interval [CI], 0.77-0.92). However, the association was attenuated and no longer statistically significant after adjusting for other risk factors (pooled multivariate RR=0.94; 95% CI, 0.86-1.03). In categorical analyses compared with dietary fiber intake of 10 to <15 g/d, the pooled multivariate RR was 1.18 (95% CI, 1.05-1.31) for less than 10 g/d (11% of the overall study population); and RR, 1.00 (95% CI, 0.85-1.17) for 30 or more g/d. Fiber intake from cereals, fruits, and vegetables was not associated with risk of colorectal cancer. The pooled multivariate RRs comparing the highest vs lowest study- and sex-specific quintile of dietary fiber intake were 1.00 (95% CI, 0.90-1.11) for colon cancer and 0.85 (95% CI, 0.72-1.01) for rectal cancer (P for common effects by tumor site=.07). Conclusions: In this large pooled analysis, dietary fiber intake was inversely associated with risk of colorectal cancer in age-adjusted analyses. However, after accounting for other dietary risk factors, high dietary fiber intake was not associated with a reduced risk of colorectal cancer.

Original languageEnglish (US)
Pages (from-to)2849-2857
Number of pages9
JournalJournal of the American Medical Association
Volume294
Issue number22
DOIs
StatePublished - Dec 14 2005

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Dietary Fiber
Colorectal Neoplasms
Cohort Studies
Prospective Studies
Confidence Intervals
Rectal Neoplasms
Proportional Hazards Models
Vegetables
Colonic Neoplasms
Observational Studies
Fruit
Neoplasms
Outcome Assessment (Health Care)
Diet

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Park, Y., Hunter, D. J., Spiegelman, D., Bergkvist, L., Berrino, F., Van Den Brandt, P. A., ... Smith-Warner, S. A. (2005). Dietary fiber intake and risk of colorectal cancer: A pooled analysis of prospective cohort studies. Journal of the American Medical Association, 294(22), 2849-2857. https://doi.org/10.1001/jama.294.22.2849

Dietary fiber intake and risk of colorectal cancer : A pooled analysis of prospective cohort studies. / Park, Yikyung; Hunter, David J.; Spiegelman, Donna; Bergkvist, Leif; Berrino, Franco; Van Den Brandt, Piet A.; Buring, Julie E.; Colditz, Graham A.; Freudenheim, Jo L.; Fuchs, Charles S.; Giovannucci, Edward; Goldbohm, R. Alexandra; Graham, Saxon; Harnack, Lisa; Hartman, Anne M.; Jacobs, David R.; Kato, Ikuko; Krogh, Vittorio; Leitzmann, Michael F.; McCullough, Marjorie L.; Miller, Anthony B.; Pietinen, Pirjo; Rohan, Thomas E.; Schatzkin, Arthur; Willett, Walter C.; Wolk, Alicja; Zeleniuch-Jacquotte, Anne; Zhang, Shumin M.; Smith-Warner, Stephanie A.

In: Journal of the American Medical Association, Vol. 294, No. 22, 14.12.2005, p. 2849-2857.

Research output: Contribution to journalArticle

Park, Y, Hunter, DJ, Spiegelman, D, Bergkvist, L, Berrino, F, Van Den Brandt, PA, Buring, JE, Colditz, GA, Freudenheim, JL, Fuchs, CS, Giovannucci, E, Goldbohm, RA, Graham, S, Harnack, L, Hartman, AM, Jacobs, DR, Kato, I, Krogh, V, Leitzmann, MF, McCullough, ML, Miller, AB, Pietinen, P, Rohan, TE, Schatzkin, A, Willett, WC, Wolk, A, Zeleniuch-Jacquotte, A, Zhang, SM & Smith-Warner, SA 2005, 'Dietary fiber intake and risk of colorectal cancer: A pooled analysis of prospective cohort studies', Journal of the American Medical Association, vol. 294, no. 22, pp. 2849-2857. https://doi.org/10.1001/jama.294.22.2849
Park, Yikyung ; Hunter, David J. ; Spiegelman, Donna ; Bergkvist, Leif ; Berrino, Franco ; Van Den Brandt, Piet A. ; Buring, Julie E. ; Colditz, Graham A. ; Freudenheim, Jo L. ; Fuchs, Charles S. ; Giovannucci, Edward ; Goldbohm, R. Alexandra ; Graham, Saxon ; Harnack, Lisa ; Hartman, Anne M. ; Jacobs, David R. ; Kato, Ikuko ; Krogh, Vittorio ; Leitzmann, Michael F. ; McCullough, Marjorie L. ; Miller, Anthony B. ; Pietinen, Pirjo ; Rohan, Thomas E. ; Schatzkin, Arthur ; Willett, Walter C. ; Wolk, Alicja ; Zeleniuch-Jacquotte, Anne ; Zhang, Shumin M. ; Smith-Warner, Stephanie A. / Dietary fiber intake and risk of colorectal cancer : A pooled analysis of prospective cohort studies. In: Journal of the American Medical Association. 2005 ; Vol. 294, No. 22. pp. 2849-2857.
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title = "Dietary fiber intake and risk of colorectal cancer: A pooled analysis of prospective cohort studies",
abstract = "Context: Inconsistent findings from observational studies have continued the controversy over the effects of dietary fiber on colorectal cancer. Objective: To evaluate the association between dietary fiber intake and risk of colorectal cancer. Design, Setting, and Participants: From 13 prospective cohort studies included in the Pooling Project of Prospective Studies of Diet and Cancer, 725 628 men and women were followed up for 6 to 20 years across studies. Study- and sex-specific relative risks (RRs) were estimated with the Cox proportional hazards model and were subsequently pooled using a random-effects model. Main Outcome Measure: Incident colorectal cancer. Results: During 6 to 20 years of follow-up across studies, 8081 colorectal cancer cases were identified. For comparison of the highest vs lowest study- and sex-specific quintile of dietary fiber intake, a significant inverse association was found in the age-adjusted model (pooled RR=0.84; 95{\%} confidence interval [CI], 0.77-0.92). However, the association was attenuated and no longer statistically significant after adjusting for other risk factors (pooled multivariate RR=0.94; 95{\%} CI, 0.86-1.03). In categorical analyses compared with dietary fiber intake of 10 to <15 g/d, the pooled multivariate RR was 1.18 (95{\%} CI, 1.05-1.31) for less than 10 g/d (11{\%} of the overall study population); and RR, 1.00 (95{\%} CI, 0.85-1.17) for 30 or more g/d. Fiber intake from cereals, fruits, and vegetables was not associated with risk of colorectal cancer. The pooled multivariate RRs comparing the highest vs lowest study- and sex-specific quintile of dietary fiber intake were 1.00 (95{\%} CI, 0.90-1.11) for colon cancer and 0.85 (95{\%} CI, 0.72-1.01) for rectal cancer (P for common effects by tumor site=.07). Conclusions: In this large pooled analysis, dietary fiber intake was inversely associated with risk of colorectal cancer in age-adjusted analyses. However, after accounting for other dietary risk factors, high dietary fiber intake was not associated with a reduced risk of colorectal cancer.",
author = "Yikyung Park and Hunter, {David J.} and Donna Spiegelman and Leif Bergkvist and Franco Berrino and {Van Den Brandt}, {Piet A.} and Buring, {Julie E.} and Colditz, {Graham A.} and Freudenheim, {Jo L.} and Fuchs, {Charles S.} and Edward Giovannucci and Goldbohm, {R. Alexandra} and Saxon Graham and Lisa Harnack and Hartman, {Anne M.} and Jacobs, {David R.} and Ikuko Kato and Vittorio Krogh and Leitzmann, {Michael F.} and McCullough, {Marjorie L.} and Miller, {Anthony B.} and Pirjo Pietinen and Rohan, {Thomas E.} and Arthur Schatzkin and Willett, {Walter C.} and Alicja Wolk and Anne Zeleniuch-Jacquotte and Zhang, {Shumin M.} and Smith-Warner, {Stephanie A.}",
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TY - JOUR

T1 - Dietary fiber intake and risk of colorectal cancer

T2 - A pooled analysis of prospective cohort studies

AU - Park, Yikyung

AU - Hunter, David J.

AU - Spiegelman, Donna

AU - Bergkvist, Leif

AU - Berrino, Franco

AU - Van Den Brandt, Piet A.

AU - Buring, Julie E.

AU - Colditz, Graham A.

AU - Freudenheim, Jo L.

AU - Fuchs, Charles S.

AU - Giovannucci, Edward

AU - Goldbohm, R. Alexandra

AU - Graham, Saxon

AU - Harnack, Lisa

AU - Hartman, Anne M.

AU - Jacobs, David R.

AU - Kato, Ikuko

AU - Krogh, Vittorio

AU - Leitzmann, Michael F.

AU - McCullough, Marjorie L.

AU - Miller, Anthony B.

AU - Pietinen, Pirjo

AU - Rohan, Thomas E.

AU - Schatzkin, Arthur

AU - Willett, Walter C.

AU - Wolk, Alicja

AU - Zeleniuch-Jacquotte, Anne

AU - Zhang, Shumin M.

AU - Smith-Warner, Stephanie A.

PY - 2005/12/14

Y1 - 2005/12/14

N2 - Context: Inconsistent findings from observational studies have continued the controversy over the effects of dietary fiber on colorectal cancer. Objective: To evaluate the association between dietary fiber intake and risk of colorectal cancer. Design, Setting, and Participants: From 13 prospective cohort studies included in the Pooling Project of Prospective Studies of Diet and Cancer, 725 628 men and women were followed up for 6 to 20 years across studies. Study- and sex-specific relative risks (RRs) were estimated with the Cox proportional hazards model and were subsequently pooled using a random-effects model. Main Outcome Measure: Incident colorectal cancer. Results: During 6 to 20 years of follow-up across studies, 8081 colorectal cancer cases were identified. For comparison of the highest vs lowest study- and sex-specific quintile of dietary fiber intake, a significant inverse association was found in the age-adjusted model (pooled RR=0.84; 95% confidence interval [CI], 0.77-0.92). However, the association was attenuated and no longer statistically significant after adjusting for other risk factors (pooled multivariate RR=0.94; 95% CI, 0.86-1.03). In categorical analyses compared with dietary fiber intake of 10 to <15 g/d, the pooled multivariate RR was 1.18 (95% CI, 1.05-1.31) for less than 10 g/d (11% of the overall study population); and RR, 1.00 (95% CI, 0.85-1.17) for 30 or more g/d. Fiber intake from cereals, fruits, and vegetables was not associated with risk of colorectal cancer. The pooled multivariate RRs comparing the highest vs lowest study- and sex-specific quintile of dietary fiber intake were 1.00 (95% CI, 0.90-1.11) for colon cancer and 0.85 (95% CI, 0.72-1.01) for rectal cancer (P for common effects by tumor site=.07). Conclusions: In this large pooled analysis, dietary fiber intake was inversely associated with risk of colorectal cancer in age-adjusted analyses. However, after accounting for other dietary risk factors, high dietary fiber intake was not associated with a reduced risk of colorectal cancer.

AB - Context: Inconsistent findings from observational studies have continued the controversy over the effects of dietary fiber on colorectal cancer. Objective: To evaluate the association between dietary fiber intake and risk of colorectal cancer. Design, Setting, and Participants: From 13 prospective cohort studies included in the Pooling Project of Prospective Studies of Diet and Cancer, 725 628 men and women were followed up for 6 to 20 years across studies. Study- and sex-specific relative risks (RRs) were estimated with the Cox proportional hazards model and were subsequently pooled using a random-effects model. Main Outcome Measure: Incident colorectal cancer. Results: During 6 to 20 years of follow-up across studies, 8081 colorectal cancer cases were identified. For comparison of the highest vs lowest study- and sex-specific quintile of dietary fiber intake, a significant inverse association was found in the age-adjusted model (pooled RR=0.84; 95% confidence interval [CI], 0.77-0.92). However, the association was attenuated and no longer statistically significant after adjusting for other risk factors (pooled multivariate RR=0.94; 95% CI, 0.86-1.03). In categorical analyses compared with dietary fiber intake of 10 to <15 g/d, the pooled multivariate RR was 1.18 (95% CI, 1.05-1.31) for less than 10 g/d (11% of the overall study population); and RR, 1.00 (95% CI, 0.85-1.17) for 30 or more g/d. Fiber intake from cereals, fruits, and vegetables was not associated with risk of colorectal cancer. The pooled multivariate RRs comparing the highest vs lowest study- and sex-specific quintile of dietary fiber intake were 1.00 (95% CI, 0.90-1.11) for colon cancer and 0.85 (95% CI, 0.72-1.01) for rectal cancer (P for common effects by tumor site=.07). Conclusions: In this large pooled analysis, dietary fiber intake was inversely associated with risk of colorectal cancer in age-adjusted analyses. However, after accounting for other dietary risk factors, high dietary fiber intake was not associated with a reduced risk of colorectal cancer.

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