Dietary factors and risk of prostate cancer: a case-control study in Ontario, Canada

Thomas E. Rohan, Geoffrey R. Howe, J. David Burch, Meera Jain

Research output: Contribution to journalArticle

123 Citations (Scopus)

Abstract

The relationship between risk of prostate cancer and dietary intake of energy, fat, vitamin A, and other nutrients was investigated in a case-control study conducted in Ontario, Canada. Cases were men with a recent, histologically confirmed diagnosis of adenocarcinoma of the prostate notified to the Ontario Cancer Registry between April 1990 and April 1992. Controls were selected randomly from assessment lists maintained by the Ontario Ministry of Revenue, and were frequency-matched to the cases on age. The study included 207 cases (51.4 percent of those eligible) and 207 controls (39.4 percent of those eligible), and information on dietary intake was collected from them by means of a quantitative diet history. There was a positive association between energy intake and risk of prostate cancer, such that men at the uppermost quartile level of energy intake had a 75 percent increase in risk. In contrast, there was no clear association between the non-energy effects of total fat and monounsaturated fat intake and prostate cancer risk. There was some evidence for an inverse association with saturated fat intake, although the dose-response pattern was irregular. There was a weak (statistically nonsignificant) positive association between polyunsaturated fat intake and risk of prostate cancer. Relatively high levels of retinol intake were associated with reduced risk, but there was essentially no association between dietary β-carotene intake and risk. There was no alteration in risk in association with dietary fiber, cholesterol, and vitamins C and E. Although these patterns were evident both overall and within age-strata, and persisted after adjustment for a number of potential confounding factors, they could reflect (in particular) the effect of nonrespondent bias.

Original languageEnglish (US)
Pages (from-to)145-154
Number of pages10
JournalCancer Causes and Control
Volume6
Issue number2
DOIs
StatePublished - Mar 1995
Externally publishedYes

Fingerprint

Ontario
Canada
Case-Control Studies
Prostatic Neoplasms
Fats
Energy Intake
Vitamin A
Dietary Cholesterol
Dietary Fiber
Carotenoids
Vitamin E
Ascorbic Acid
Registries
Prostate
Adenocarcinoma
Diet
Food

Keywords

  • Canada
  • case-control study
  • diet
  • males
  • prostate cancer

ASJC Scopus subject areas

  • Oncology
  • Epidemiology
  • Cancer Research

Cite this

Dietary factors and risk of prostate cancer : a case-control study in Ontario, Canada. / Rohan, Thomas E.; Howe, Geoffrey R.; David Burch, J.; Jain, Meera.

In: Cancer Causes and Control, Vol. 6, No. 2, 03.1995, p. 145-154.

Research output: Contribution to journalArticle

Rohan, Thomas E. ; Howe, Geoffrey R. ; David Burch, J. ; Jain, Meera. / Dietary factors and risk of prostate cancer : a case-control study in Ontario, Canada. In: Cancer Causes and Control. 1995 ; Vol. 6, No. 2. pp. 145-154.
@article{d75eccbdb1664a948c2141aaae2f062f,
title = "Dietary factors and risk of prostate cancer: a case-control study in Ontario, Canada",
abstract = "The relationship between risk of prostate cancer and dietary intake of energy, fat, vitamin A, and other nutrients was investigated in a case-control study conducted in Ontario, Canada. Cases were men with a recent, histologically confirmed diagnosis of adenocarcinoma of the prostate notified to the Ontario Cancer Registry between April 1990 and April 1992. Controls were selected randomly from assessment lists maintained by the Ontario Ministry of Revenue, and were frequency-matched to the cases on age. The study included 207 cases (51.4 percent of those eligible) and 207 controls (39.4 percent of those eligible), and information on dietary intake was collected from them by means of a quantitative diet history. There was a positive association between energy intake and risk of prostate cancer, such that men at the uppermost quartile level of energy intake had a 75 percent increase in risk. In contrast, there was no clear association between the non-energy effects of total fat and monounsaturated fat intake and prostate cancer risk. There was some evidence for an inverse association with saturated fat intake, although the dose-response pattern was irregular. There was a weak (statistically nonsignificant) positive association between polyunsaturated fat intake and risk of prostate cancer. Relatively high levels of retinol intake were associated with reduced risk, but there was essentially no association between dietary β-carotene intake and risk. There was no alteration in risk in association with dietary fiber, cholesterol, and vitamins C and E. Although these patterns were evident both overall and within age-strata, and persisted after adjustment for a number of potential confounding factors, they could reflect (in particular) the effect of nonrespondent bias.",
keywords = "Canada, case-control study, diet, males, prostate cancer",
author = "Rohan, {Thomas E.} and Howe, {Geoffrey R.} and {David Burch}, J. and Meera Jain",
year = "1995",
month = "3",
doi = "10.1007/BF00052775",
language = "English (US)",
volume = "6",
pages = "145--154",
journal = "Cancer Causes and Control",
issn = "0957-5243",
publisher = "Springer Netherlands",
number = "2",

}

TY - JOUR

T1 - Dietary factors and risk of prostate cancer

T2 - a case-control study in Ontario, Canada

AU - Rohan, Thomas E.

AU - Howe, Geoffrey R.

AU - David Burch, J.

AU - Jain, Meera

PY - 1995/3

Y1 - 1995/3

N2 - The relationship between risk of prostate cancer and dietary intake of energy, fat, vitamin A, and other nutrients was investigated in a case-control study conducted in Ontario, Canada. Cases were men with a recent, histologically confirmed diagnosis of adenocarcinoma of the prostate notified to the Ontario Cancer Registry between April 1990 and April 1992. Controls were selected randomly from assessment lists maintained by the Ontario Ministry of Revenue, and were frequency-matched to the cases on age. The study included 207 cases (51.4 percent of those eligible) and 207 controls (39.4 percent of those eligible), and information on dietary intake was collected from them by means of a quantitative diet history. There was a positive association between energy intake and risk of prostate cancer, such that men at the uppermost quartile level of energy intake had a 75 percent increase in risk. In contrast, there was no clear association between the non-energy effects of total fat and monounsaturated fat intake and prostate cancer risk. There was some evidence for an inverse association with saturated fat intake, although the dose-response pattern was irregular. There was a weak (statistically nonsignificant) positive association between polyunsaturated fat intake and risk of prostate cancer. Relatively high levels of retinol intake were associated with reduced risk, but there was essentially no association between dietary β-carotene intake and risk. There was no alteration in risk in association with dietary fiber, cholesterol, and vitamins C and E. Although these patterns were evident both overall and within age-strata, and persisted after adjustment for a number of potential confounding factors, they could reflect (in particular) the effect of nonrespondent bias.

AB - The relationship between risk of prostate cancer and dietary intake of energy, fat, vitamin A, and other nutrients was investigated in a case-control study conducted in Ontario, Canada. Cases were men with a recent, histologically confirmed diagnosis of adenocarcinoma of the prostate notified to the Ontario Cancer Registry between April 1990 and April 1992. Controls were selected randomly from assessment lists maintained by the Ontario Ministry of Revenue, and were frequency-matched to the cases on age. The study included 207 cases (51.4 percent of those eligible) and 207 controls (39.4 percent of those eligible), and information on dietary intake was collected from them by means of a quantitative diet history. There was a positive association between energy intake and risk of prostate cancer, such that men at the uppermost quartile level of energy intake had a 75 percent increase in risk. In contrast, there was no clear association between the non-energy effects of total fat and monounsaturated fat intake and prostate cancer risk. There was some evidence for an inverse association with saturated fat intake, although the dose-response pattern was irregular. There was a weak (statistically nonsignificant) positive association between polyunsaturated fat intake and risk of prostate cancer. Relatively high levels of retinol intake were associated with reduced risk, but there was essentially no association between dietary β-carotene intake and risk. There was no alteration in risk in association with dietary fiber, cholesterol, and vitamins C and E. Although these patterns were evident both overall and within age-strata, and persisted after adjustment for a number of potential confounding factors, they could reflect (in particular) the effect of nonrespondent bias.

KW - Canada

KW - case-control study

KW - diet

KW - males

KW - prostate cancer

UR - http://www.scopus.com/inward/record.url?scp=0028913694&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028913694&partnerID=8YFLogxK

U2 - 10.1007/BF00052775

DO - 10.1007/BF00052775

M3 - Article

C2 - 7749054

AN - SCOPUS:0028913694

VL - 6

SP - 145

EP - 154

JO - Cancer Causes and Control

JF - Cancer Causes and Control

SN - 0957-5243

IS - 2

ER -