TY - JOUR
T1 - Dietary factors and risk of breast cancer
T2 - Combined analysis of 12 case - control studies
AU - Howe, Geoffrey R.
AU - Hirohata, Tomio
AU - Hislop, T. Gregory
AU - Iscovich, Jose Mario
AU - Yuan, Jian Min
AU - Katsouyanni, Klea
AU - Lubin, Flora
AU - Marubini, Ettore
AU - Modan, Baruch
AU - Rohan, Thomas
AU - Toniolo, Paolo
AU - Shunzhang, Yu
N1 - Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
PY - 1990/4/4
Y1 - 1990/4/4
N2 - We conducted a combined analysis of the original data to evaluate the consistency of 12 case-control studies of diet and breast cancer. Our analysis shows a consistent, statistically significant, positive association between breast cancer risk and saturated fat intake in postmenopausal women (relative risk for highest vs. lowest quintile, 1.46; P <.0001). A consistent protective effect for a number of markers of fruit and vegetable intake was demonstrated; vitamin C intake had the most consistent and statistically significant inverse association with breast cancer risk (relative risk for highest vs. lowest quintile, 0.69; P <.0001). If these dietary associations represent causality, the attributable risk (i.e., the percentage of breast cancers that might be prevented by dietary modification) in the North American population is estimated to be 24% for postmenopausal women and 16% for premeno-pausal women. [J Natl Cancer Inst 82: 561-569, 1990]
AB - We conducted a combined analysis of the original data to evaluate the consistency of 12 case-control studies of diet and breast cancer. Our analysis shows a consistent, statistically significant, positive association between breast cancer risk and saturated fat intake in postmenopausal women (relative risk for highest vs. lowest quintile, 1.46; P <.0001). A consistent protective effect for a number of markers of fruit and vegetable intake was demonstrated; vitamin C intake had the most consistent and statistically significant inverse association with breast cancer risk (relative risk for highest vs. lowest quintile, 0.69; P <.0001). If these dietary associations represent causality, the attributable risk (i.e., the percentage of breast cancers that might be prevented by dietary modification) in the North American population is estimated to be 24% for postmenopausal women and 16% for premeno-pausal women. [J Natl Cancer Inst 82: 561-569, 1990]
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U2 - 10.1093/jnci/82.7.561
DO - 10.1093/jnci/82.7.561
M3 - Review article
C2 - 2156081
AN - SCOPUS:0025209997
SN - 0027-8874
VL - 82
SP - 561
EP - 569
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 7
ER -