Dietary components modify gene expression: Implications for carcinogenesis

Kan Yang, WanCai Yang, John Mariadason, Anna Velcich, Martin Lipkin, Leonard H. Augenlicht

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Mouse genetic models that probe important pathways in intestinal cell maturation, such as cell-cycle regulation, apoptosis, and, especially, lineage specific differentiation, have provided profound insight into the underlying mechanisms of intestinal tumor formation and progression. However, a wealth of epidemiological and experimental data indicates that environment, especially the diet, is a principal determinant of relative risk for tumor development. We have demonstrated that even in mouse models in which tumor incidence is strongly initiated by genetic manipulation of genes, such as Apc, p21 WAF1/cip1, and p27Kip1, a Western-style diet that is high in fat and low in calcium and vitamin D can dramatically increase and accelerate tumor formation. Moreover, experiments show that modulation of calcium and vitamin D levels can substantially influence tumor formation in both the mouse genetic models, as well as in a new dietary model that appears to mimic the development of sporadic colon cancer. Finally, analysis of gene expression profiles provides important insights into how diets may alter metabolic profiles and regulatory pathways that influence probability of tumor formation in the histologically and physiologically normal intestinal mucosa.

Original languageEnglish (US)
Pages (from-to)2710-2714
Number of pages5
JournalJournal of Nutrition
Volume135
Issue number11
StatePublished - Nov 2005

Fingerprint

carcinogenesis
Carcinogenesis
Gene Expression
gene expression
neoplasms
Neoplasms
Genetic Models
Diet
vitamin D
Vitamin D
diet
Calcium
calcium
Metabolome
mice
relative risk
Intestinal Mucosa
intestinal mucosa
colorectal neoplasms
genetic engineering

Keywords

  • Colon cancer
  • Gene expression
  • Western-style diet

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Yang, K., Yang, W., Mariadason, J., Velcich, A., Lipkin, M., & Augenlicht, L. H. (2005). Dietary components modify gene expression: Implications for carcinogenesis. Journal of Nutrition, 135(11), 2710-2714.

Dietary components modify gene expression : Implications for carcinogenesis. / Yang, Kan; Yang, WanCai; Mariadason, John; Velcich, Anna; Lipkin, Martin; Augenlicht, Leonard H.

In: Journal of Nutrition, Vol. 135, No. 11, 11.2005, p. 2710-2714.

Research output: Contribution to journalArticle

Yang, K, Yang, W, Mariadason, J, Velcich, A, Lipkin, M & Augenlicht, LH 2005, 'Dietary components modify gene expression: Implications for carcinogenesis', Journal of Nutrition, vol. 135, no. 11, pp. 2710-2714.
Yang K, Yang W, Mariadason J, Velcich A, Lipkin M, Augenlicht LH. Dietary components modify gene expression: Implications for carcinogenesis. Journal of Nutrition. 2005 Nov;135(11):2710-2714.
Yang, Kan ; Yang, WanCai ; Mariadason, John ; Velcich, Anna ; Lipkin, Martin ; Augenlicht, Leonard H. / Dietary components modify gene expression : Implications for carcinogenesis. In: Journal of Nutrition. 2005 ; Vol. 135, No. 11. pp. 2710-2714.
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