Dietary carotenoid intake and colorectal cancer risk

Paul Terry, Meera Jain, Anthony B. Miller, Geoffrey R. Howe, Thomas E. Rohan

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Several studies have found inverse associations between fruit and vegetable consumption and colorectal cancer risk, suggesting the potential etiological importance of carotenoids (and other phytochemicals) contained in these foods. However, only one study (a case-control study) has examined the association between dietary carotenoids other than β-carotene and colorectal cancer risk. In the study reported here, we examined the relationships between dietary intakes of β-carotene, α-carotene, lycopene, lutein, and β-cryptoxanthin and colorectal cancer risk in a large cohort study of Canadian women. A case-cohort analysis was undertaken within the cohort of 56,837 women who were enrolled in the Canadian National Breast Screening Study and who completed a self-administered dietary questionnaire. During follow-up to the end of 1993, a total of 388 women were diagnosed with colorectal cancer. For comparative purposes, a subcohort of 5,681 women was randomly selected. After exclusions for various reasons, the analyses were based on 295 cases and 5,334 noncases. We did not find any clear association between intake of any of the studied carotenoids and colorectal cancer risk in the study population as a whole or in subgroups defined by smoking status, relative body weight (body mass index), intakes of total fat, energy, alcohol, and folic acid, or menopausal status. Our data do not support any association between dietary intakes of the studied carotenoids and colorectal cancer risk. However, given that this is the first prospective cohort study of carotenoids in relation to colorectal cancer, further studies are warranted.

Original languageEnglish (US)
Pages (from-to)167-172
Number of pages6
JournalNutrition and Cancer
Volume42
Issue number2
StatePublished - 2002

Fingerprint

Carotenoids
colorectal neoplasms
Colorectal Neoplasms
carotenoids
carotenes
Cohort Studies
cohort studies
food intake
Lutein
menopause
smoking (food products)
vegetable consumption
fruit consumption
Phytochemicals
lycopene
case-control studies
lutein
Folic Acid
folic acid
Vegetables

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Oncology
  • Food Science

Cite this

Terry, P., Jain, M., Miller, A. B., Howe, G. R., & Rohan, T. E. (2002). Dietary carotenoid intake and colorectal cancer risk. Nutrition and Cancer, 42(2), 167-172.

Dietary carotenoid intake and colorectal cancer risk. / Terry, Paul; Jain, Meera; Miller, Anthony B.; Howe, Geoffrey R.; Rohan, Thomas E.

In: Nutrition and Cancer, Vol. 42, No. 2, 2002, p. 167-172.

Research output: Contribution to journalArticle

Terry, P, Jain, M, Miller, AB, Howe, GR & Rohan, TE 2002, 'Dietary carotenoid intake and colorectal cancer risk', Nutrition and Cancer, vol. 42, no. 2, pp. 167-172.
Terry P, Jain M, Miller AB, Howe GR, Rohan TE. Dietary carotenoid intake and colorectal cancer risk. Nutrition and Cancer. 2002;42(2):167-172.
Terry, Paul ; Jain, Meera ; Miller, Anthony B. ; Howe, Geoffrey R. ; Rohan, Thomas E. / Dietary carotenoid intake and colorectal cancer risk. In: Nutrition and Cancer. 2002 ; Vol. 42, No. 2. pp. 167-172.
@article{fc2c52bb2a114309a6b63b0b8bc448f3,
title = "Dietary carotenoid intake and colorectal cancer risk",
abstract = "Several studies have found inverse associations between fruit and vegetable consumption and colorectal cancer risk, suggesting the potential etiological importance of carotenoids (and other phytochemicals) contained in these foods. However, only one study (a case-control study) has examined the association between dietary carotenoids other than β-carotene and colorectal cancer risk. In the study reported here, we examined the relationships between dietary intakes of β-carotene, α-carotene, lycopene, lutein, and β-cryptoxanthin and colorectal cancer risk in a large cohort study of Canadian women. A case-cohort analysis was undertaken within the cohort of 56,837 women who were enrolled in the Canadian National Breast Screening Study and who completed a self-administered dietary questionnaire. During follow-up to the end of 1993, a total of 388 women were diagnosed with colorectal cancer. For comparative purposes, a subcohort of 5,681 women was randomly selected. After exclusions for various reasons, the analyses were based on 295 cases and 5,334 noncases. We did not find any clear association between intake of any of the studied carotenoids and colorectal cancer risk in the study population as a whole or in subgroups defined by smoking status, relative body weight (body mass index), intakes of total fat, energy, alcohol, and folic acid, or menopausal status. Our data do not support any association between dietary intakes of the studied carotenoids and colorectal cancer risk. However, given that this is the first prospective cohort study of carotenoids in relation to colorectal cancer, further studies are warranted.",
author = "Paul Terry and Meera Jain and Miller, {Anthony B.} and Howe, {Geoffrey R.} and Rohan, {Thomas E.}",
year = "2002",
language = "English (US)",
volume = "42",
pages = "167--172",
journal = "Nutrition and Cancer",
issn = "0163-5581",
publisher = "Routledge",
number = "2",

}

TY - JOUR

T1 - Dietary carotenoid intake and colorectal cancer risk

AU - Terry, Paul

AU - Jain, Meera

AU - Miller, Anthony B.

AU - Howe, Geoffrey R.

AU - Rohan, Thomas E.

PY - 2002

Y1 - 2002

N2 - Several studies have found inverse associations between fruit and vegetable consumption and colorectal cancer risk, suggesting the potential etiological importance of carotenoids (and other phytochemicals) contained in these foods. However, only one study (a case-control study) has examined the association between dietary carotenoids other than β-carotene and colorectal cancer risk. In the study reported here, we examined the relationships between dietary intakes of β-carotene, α-carotene, lycopene, lutein, and β-cryptoxanthin and colorectal cancer risk in a large cohort study of Canadian women. A case-cohort analysis was undertaken within the cohort of 56,837 women who were enrolled in the Canadian National Breast Screening Study and who completed a self-administered dietary questionnaire. During follow-up to the end of 1993, a total of 388 women were diagnosed with colorectal cancer. For comparative purposes, a subcohort of 5,681 women was randomly selected. After exclusions for various reasons, the analyses were based on 295 cases and 5,334 noncases. We did not find any clear association between intake of any of the studied carotenoids and colorectal cancer risk in the study population as a whole or in subgroups defined by smoking status, relative body weight (body mass index), intakes of total fat, energy, alcohol, and folic acid, or menopausal status. Our data do not support any association between dietary intakes of the studied carotenoids and colorectal cancer risk. However, given that this is the first prospective cohort study of carotenoids in relation to colorectal cancer, further studies are warranted.

AB - Several studies have found inverse associations between fruit and vegetable consumption and colorectal cancer risk, suggesting the potential etiological importance of carotenoids (and other phytochemicals) contained in these foods. However, only one study (a case-control study) has examined the association between dietary carotenoids other than β-carotene and colorectal cancer risk. In the study reported here, we examined the relationships between dietary intakes of β-carotene, α-carotene, lycopene, lutein, and β-cryptoxanthin and colorectal cancer risk in a large cohort study of Canadian women. A case-cohort analysis was undertaken within the cohort of 56,837 women who were enrolled in the Canadian National Breast Screening Study and who completed a self-administered dietary questionnaire. During follow-up to the end of 1993, a total of 388 women were diagnosed with colorectal cancer. For comparative purposes, a subcohort of 5,681 women was randomly selected. After exclusions for various reasons, the analyses were based on 295 cases and 5,334 noncases. We did not find any clear association between intake of any of the studied carotenoids and colorectal cancer risk in the study population as a whole or in subgroups defined by smoking status, relative body weight (body mass index), intakes of total fat, energy, alcohol, and folic acid, or menopausal status. Our data do not support any association between dietary intakes of the studied carotenoids and colorectal cancer risk. However, given that this is the first prospective cohort study of carotenoids in relation to colorectal cancer, further studies are warranted.

UR - http://www.scopus.com/inward/record.url?scp=0036034169&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036034169&partnerID=8YFLogxK

M3 - Article

VL - 42

SP - 167

EP - 172

JO - Nutrition and Cancer

JF - Nutrition and Cancer

SN - 0163-5581

IS - 2

ER -