Diet quality and genetic association with body mass index: Results from 3 observational studies

Ming Ding, Christina Ellervik, Tao Huang, Majken K. Jensen, Gary C. Curhan, Louis R. Pasquale, Jae H. Kang, Janey L. Wiggs, David J. Hunter, Walter C. Willett, Eric B. Rimm, Peter Kraft, Daniel I. Chasman, Lu Qi, Frank B. Hu, Qibin Qi

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Background: It is unknown whether dietary quality modifies genetic association with body mass index (BMI). Objective: This study examined whether dietary quality modifies genetic association with BMI. Design: We calculated 3 diet quality scores including the Alternative Healthy Eating Index 2010 (AHEI-2010), the Alternative Mediterranean Diet score (AMED), and the Dietary Approach to Stop Hypertension (DASH) diet score. We examined the interactions of a genetic risk score (GRS) based on 97 BMI-associated variants with the 3 diet quality scores on BMI in 30,904 participants from 3 large cohorts. Results: We found significant interactions between total GRS and all 3 diet scores on BMI assessed after 2-3 y, with an attenuated genetic effect observed in individuals with healthier diets (AHEI: P-interaction = 0.003; AMED: P = 0.001; DASH: P = 0.004). For example, the difference in BMI (kg/m 2 ) per 10-unit increment of the GRS was smaller among participants in the highest tertile of AHEI score compared with those in the lowest tertile (0.84; 95% CI: 0.72, 0.96 compared with 1.14; 95% CI: 0.99, 1.29). Results were consistent across the 3 cohorts with no significant heterogeneity. The interactions with diet scores on BMI appeared more significant for central nervous system GRSs (P < 0.01 for 3 diet scores) than for non-central nervous system GRSs (P > 0.05 for 3 diet scores). Conclusions: A higher diet quality attenuated genetic predisposition to obesity. These findings underscore the importance of maintaining a healthful diet for the prevention of obesity, particularly for those individuals with a strong genetic predisposition to obesity.

Original languageEnglish (US)
Pages (from-to)1291-1300
Number of pages10
JournalAmerican Journal of Clinical Nutrition
Volume108
Issue number6
DOIs
StatePublished - 2018

Keywords

  • Body mass index
  • Diet scores
  • Genetic risk score

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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    Ding, M., Ellervik, C., Huang, T., Jensen, M. K., Curhan, G. C., Pasquale, L. R., Kang, J. H., Wiggs, J. L., Hunter, D. J., Willett, W. C., Rimm, E. B., Kraft, P., Chasman, D. I., Qi, L., Hu, F. B., & Qi, Q. (2018). Diet quality and genetic association with body mass index: Results from 3 observational studies. American Journal of Clinical Nutrition, 108(6), 1291-1300. https://doi.org/10.1093/ajcn/nqy203