Diet Quality and Colorectal Cancer Risk in the Women's Health Initiative Observational Study

Ashley J. Vargas, Marian L. Neuhouser, Stephanie M. George, Cynthia A. Thomson, Gloria Y F Ho, Thomas E. Rohan, Ikuko Kato, Rami Nassir, Lifang Hou, Joann E. Manson

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Diet quality index scores on Healthy Eating Index 2010 (HEI-2010), Alternative HEI-2010, alternative Mediterranean Diet Index, and the Dietary Approaches to Stop Hypertension (DASH) index have been inversely associated with all-cause and cancer-specific death. This study assessed the association between these scores and colorectal cancer (CRC) incidence as well as CRC-specific mortality in the Women's Health Initiative Observational Study (1993-2012), a US study of postmenopausal women. During an average of 12.4 years of follow-up, there were 938 cases of CRC and 238 CRC-specific deaths. We estimated multivariate hazard ratios and 95% confidence intervals for relationships between quintiles of diet scores (from baseline food frequency questionnaires) and outcomes. HEI-2010 score (hazard ratios were 0.81, 0.77, and 0.73 with P values of 0.04, 0.01, and

Original languageEnglish (US)
Pages (from-to)23-32
Number of pages10
JournalAmerican Journal of Epidemiology
Volume184
Issue number1
DOIs
StatePublished - Jul 1 2016
Externally publishedYes

Keywords

  • Alternative Healthy Eating Index
  • Alternative Mediterranean Diet
  • colorectal cancer
  • diet
  • diet quality
  • Dietary Approaches to Stop Hypertension
  • dietary patterns
  • Healthy Eating Index

ASJC Scopus subject areas

  • Epidemiology

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    Vargas, A. J., Neuhouser, M. L., George, S. M., Thomson, C. A., Ho, G. Y. F., Rohan, T. E., Kato, I., Nassir, R., Hou, L., & Manson, J. E. (2016). Diet Quality and Colorectal Cancer Risk in the Women's Health Initiative Observational Study. American Journal of Epidemiology, 184(1), 23-32. https://doi.org/10.1093/aje/kwv304