Diet Quality and Colorectal Cancer Risk in the Women's Health Initiative Observational Study

Ashley J. Vargas, Marian L. Neuhouser, Stephanie M. George, Cynthia A. Thomson, Gloria Yuen Fun Ho, Thomas E. Rohan, Ikuko Kato, Rami Nassir, Lifang Hou, Joann E. Manson

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Diet quality index scores on Healthy Eating Index 2010 (HEI-2010), Alternative HEI-2010, alternative Mediterranean Diet Index, and the Dietary Approaches to Stop Hypertension (DASH) index have been inversely associated with all-cause and cancer-specific death. This study assessed the association between these scores and colorectal cancer (CRC) incidence as well as CRC-specific mortality in the Women's Health Initiative Observational Study (1993-2012), a US study of postmenopausal women. During an average of 12.4 years of follow-up, there were 938 cases of CRC and 238 CRC-specific deaths. We estimated multivariate hazard ratios and 95% confidence intervals for relationships between quintiles of diet scores (from baseline food frequency questionnaires) and outcomes. HEI-2010 score (hazard ratios were 0.81, 0.77, and 0.73 with P values of 0.04, 0.01, and

Original languageEnglish (US)
Pages (from-to)23-32
Number of pages10
JournalAmerican Journal of Epidemiology
Volume184
Issue number1
DOIs
StatePublished - Jul 1 2016
Externally publishedYes

Keywords

  • Alternative Healthy Eating Index
  • Alternative Mediterranean Diet
  • colorectal cancer
  • diet
  • diet quality
  • Dietary Approaches to Stop Hypertension
  • dietary patterns
  • Healthy Eating Index

ASJC Scopus subject areas

  • Epidemiology

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    Vargas, A. J., Neuhouser, M. L., George, S. M., Thomson, C. A., Ho, G. Y. F., Rohan, T. E., Kato, I., Nassir, R., Hou, L., & Manson, J. E. (2016). Diet Quality and Colorectal Cancer Risk in the Women's Health Initiative Observational Study. American Journal of Epidemiology, 184(1), 23-32. https://doi.org/10.1093/aje/kwv304