TY - JOUR
T1 - Diet and risk of multiple myeloma in Connecticut women
AU - Hosgood, H. Dean
AU - Baris, Dalsu
AU - Zahm, Shelia Hoar
AU - Zheng, Tongzhang
AU - Cross, Amanda J.
N1 - Funding Information:
Acknowledgment This work was supported in part by the Yale University—National Cancer Institute Partnership Pre-Doctoral Fellowship Training Program (NCI TU2 CA105666).
PY - 2007/12
Y1 - 2007/12
N2 - Multiple myeloma accounts for an estimated 19,900 incident cancer cases per year in the United States. A population-based case-control study, consisting of 179 incident cases and 691 controls, was conducted to examine the impact of diet on multiple myeloma risk. Diet was assessed using a food frequency questionnaire and odds ratios, 95% confidence intervals, and P-trends were calculated across quartiles of consumption. After controlling for potential confounders, we observed inverse associations for cooked tomatoes (P-trend = 0.002), cruciferous vegetables (P-trend = 0.01), fresh fish (P-trend < 0.001), alcohol (P-trend < 0.001), and vitamin A (P-trend < 0.001) with multiple myeloma risk. In contrast, consumption of cream soups (P-trend = 0.01), jello (P-trend = 0.01), ice cream (P-trend = 0.01), and pudding (P-trend < 0.001) were positively associated with multiple myeloma. Furthermore, there was a suggestion that carbohydrate intake may be positively associated, whereas vitamin D and calcium intake may be inversely associated, with multiple myeloma risk. Despite very limited data on dietary factors in relation to multiple myeloma, the findings from this study concur with previously published studies, suggesting an inverse association for consumption of fish, cruciferous vegetables and green vegetables, and a positive association for some dairy products.
AB - Multiple myeloma accounts for an estimated 19,900 incident cancer cases per year in the United States. A population-based case-control study, consisting of 179 incident cases and 691 controls, was conducted to examine the impact of diet on multiple myeloma risk. Diet was assessed using a food frequency questionnaire and odds ratios, 95% confidence intervals, and P-trends were calculated across quartiles of consumption. After controlling for potential confounders, we observed inverse associations for cooked tomatoes (P-trend = 0.002), cruciferous vegetables (P-trend = 0.01), fresh fish (P-trend < 0.001), alcohol (P-trend < 0.001), and vitamin A (P-trend < 0.001) with multiple myeloma risk. In contrast, consumption of cream soups (P-trend = 0.01), jello (P-trend = 0.01), ice cream (P-trend = 0.01), and pudding (P-trend < 0.001) were positively associated with multiple myeloma. Furthermore, there was a suggestion that carbohydrate intake may be positively associated, whereas vitamin D and calcium intake may be inversely associated, with multiple myeloma risk. Despite very limited data on dietary factors in relation to multiple myeloma, the findings from this study concur with previously published studies, suggesting an inverse association for consumption of fish, cruciferous vegetables and green vegetables, and a positive association for some dairy products.
KW - Case-control
KW - Diet
KW - Multiple myeloma
KW - Risk factors
UR - http://www.scopus.com/inward/record.url?scp=34848926892&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34848926892&partnerID=8YFLogxK
U2 - 10.1007/s10552-007-9047-z
DO - 10.1007/s10552-007-9047-z
M3 - Article
C2 - 17694422
AN - SCOPUS:34848926892
SN - 0957-5243
VL - 18
SP - 1065
EP - 1076
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 10
ER -