Diagnostic ultrasound: Effects on the DNA and growth patterns of animal cells

D. Liebeskind, R. Bases, F. Elequin, S. Neubort, R. Leifer, R. Goldberg, M. Koenigsberg

Research output: Contribution to journalArticle

71 Scopus citations

Abstract

The effects of diagnostic levels of ultrasound on DNA of Hela cells included: increased immunoreactivity to antinucleoside antibodies in g1 cells, strongly suggestive of unwinding of the helix or singe-strand break induction, and low levels of non-semiconservative synthesis in logarithmically growing cells treated with hydroxyurea, indicating repair synthesis. In the C3H mouse cell line 10T-1/2, Cl 8, loss of contact inhibition with a criss-crossed growth pattern was seen. In one experiment, tumors developed in syngeneic mice at the site of infection of ultrasonically treated cells. Ultrasound in the diagnostic range appears to cause detectable effects on DNA and growth patterns of animal cells.

Original languageEnglish (US)
Pages (from-to)177-184
Number of pages8
JournalUnknown Journal
Volume131
Issue number1
DOIs
StatePublished - Jan 1 1979
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Liebeskind, D., Bases, R., Elequin, F., Neubort, S., Leifer, R., Goldberg, R., & Koenigsberg, M. (1979). Diagnostic ultrasound: Effects on the DNA and growth patterns of animal cells. Unknown Journal, 131(1), 177-184. https://doi.org/10.1148/131.1.177