TY - JOUR
T1 - Diagnostic ultrasound
T2 - Effects on the DNA and growth patterns of animal cells
AU - Liebeskind, D.
AU - Bases, R.
AU - Elequin, F.
AU - Neubort, S.
AU - Leifer, R.
AU - Goldberg, R.
AU - Koenigsberg, M.
PY - 1979/1/1
Y1 - 1979/1/1
N2 - The effects of diagnostic levels of ultrasound on DNA of Hela cells included: increased immunoreactivity to antinucleoside antibodies in g1 cells, strongly suggestive of unwinding of the helix or singe-strand break induction, and low levels of non-semiconservative synthesis in logarithmically growing cells treated with hydroxyurea, indicating repair synthesis. In the C3H mouse cell line 10T-1/2, Cl 8, loss of contact inhibition with a criss-crossed growth pattern was seen. In one experiment, tumors developed in syngeneic mice at the site of infection of ultrasonically treated cells. Ultrasound in the diagnostic range appears to cause detectable effects on DNA and growth patterns of animal cells.
AB - The effects of diagnostic levels of ultrasound on DNA of Hela cells included: increased immunoreactivity to antinucleoside antibodies in g1 cells, strongly suggestive of unwinding of the helix or singe-strand break induction, and low levels of non-semiconservative synthesis in logarithmically growing cells treated with hydroxyurea, indicating repair synthesis. In the C3H mouse cell line 10T-1/2, Cl 8, loss of contact inhibition with a criss-crossed growth pattern was seen. In one experiment, tumors developed in syngeneic mice at the site of infection of ultrasonically treated cells. Ultrasound in the diagnostic range appears to cause detectable effects on DNA and growth patterns of animal cells.
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U2 - 10.1148/131.1.177
DO - 10.1148/131.1.177
M3 - Article
C2 - 424580
AN - SCOPUS:0018377482
VL - 131
SP - 177
EP - 184
JO - Journal of Trace Elements in Medicine and Biology
JF - Journal of Trace Elements in Medicine and Biology
SN - 0946-672X
IS - 1
ER -