Abstract
Background: A syndromic gastrointestinal pathogen panel (GIP) was implemented in May 2018. All positive (+) GIP and standard-of-care (SOC) C. difficile results were reviewed. Methods: A single-center audit of adult patients with GIP results was conducted May–December 2018. We reviewed GIP(+)/SOC(+/-) and GIP(-)/SOC(-) tests (control group) for clinical outcomes. Results: We reviewed 269 GIP(+) patients. Of 119 GIP(+)/SOC(+) patients, 44 (37%) were positive by toxin A/B enzyme immunoassay, and 75 (63%) by PCR only. Thirty-day mortality and re-admission were not significantly different between groups. CDI rates within 6 months were not significantly different between GIP(+)/SOC(-) and controls (p-value = 0.39). Those with initial SOC(+) tests had more true CDI events within 6 months, compared to controls (p-values < 0.001). Conclusions: Forty percent of patients with GIP(+) C. difficile were (-) by SOC test, suggesting that true CDI was not present. Additional PCR-based testing may not impact outcomes.
Original language | English (US) |
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Article number | 115032 |
Journal | Diagnostic Microbiology and Infectious Disease |
Volume | 97 |
Issue number | 2 |
DOIs | |
State | Published - Jun 2020 |
Keywords
- Clostridiodes difficile infection
- diagnostic stewardship
- gastrointestinal pathogen panel
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases