Diagnostic imaging tests and microbial infections

Christopher J. Palestro, Charito Love, Theodore T. Miller

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Despite significant advances in the understanding of its pathogenesis, infection remains a major cause of patient morbidity and mortality. While the presence of infection may be suggested by signs and symptoms, imaging tests are often used to localize or confirm its presence. There are two principal imaging test types: morphological and functional. Morphological tests include radiographs, computed tomography (CT), magnetic resonance imaging, and sonongraphy. These procedures detect anatomic, or structural, alterations produced by microbial invasion and host response. Functional imaging tests reflect the physiological changes that are part of this process. Prototypical functional tests are radionuclide procedures such as bone, gallium, labelled leukocyte and fluorodeoxyglucose (FDG)-positron emission tomography (PET) imaging. In-line functional/morphological tomographic imaging systems, PET/CT and single photon emission tomography (SPECT)/CT, have revolutionized diagnostic imaging. These devices consist of a functional imaging device (PET or SPECT) joined together with a CT scanner. The patient undergoes both tests sequentially without leaving the examination table. Images from each study can be viewed separately and as fused images, providing precisely localized anatomic and functional information. It must be noted, however, that none of the current morphological or functional tests, either alone or in combination, are specific for infection and the goal of finding such an imaging test remains elusive.

Original languageEnglish (US)
Pages (from-to)2323-2333
Number of pages11
JournalCellular Microbiology
Volume9
Issue number10
DOIs
StatePublished - Oct 2007
Externally publishedYes

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Diagnostic Imaging
Routine Diagnostic Tests
Single-Photon Emission-Computed Tomography
Imaging techniques
Positron-Emission Tomography
Examination Tables
Infection
Tomography
X-Ray Computed Tomography Scanners
Positron emission tomography
Equipment and Supplies
Gallium
Radioisotopes
Signs and Symptoms
Leukocytes
Magnetic Resonance Imaging
Morbidity
Bone and Bones
Mortality
Single photon emission computed tomography

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Microbiology

Cite this

Diagnostic imaging tests and microbial infections. / Palestro, Christopher J.; Love, Charito; Miller, Theodore T.

In: Cellular Microbiology, Vol. 9, No. 10, 10.2007, p. 2323-2333.

Research output: Contribution to journalArticle

Palestro, Christopher J. ; Love, Charito ; Miller, Theodore T. / Diagnostic imaging tests and microbial infections. In: Cellular Microbiology. 2007 ; Vol. 9, No. 10. pp. 2323-2333.
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