Diagnostic and substance specificity of carbon-dioxide-induced panic

Laszlo A. Papp, Donald F. Klein, Jose Martinez, Frank Schneier, Randolph Cole, Michael R. Liebowitz, Eric Hollander, Abby J. Fyer, Fanchea Jordan, Jack M. Gorman

Research output: Contribution to journalArticle

126 Citations (Scopus)

Abstract

Objective: The authors assessed the substance and diagnostic specificity of carbon-dioxide-induced panic since, in addition to the specific biochemical effects of inhaled carbon dioxide (CO2), simple physiologic distress is also frequently implicated as a panicogenic factor during respiratory challenge studies with CO2 in patients with anxiety disorders. Method: Eighteen patients with panic disorder, 20 with social phobia, and 23 psychiatrically normal subjects inhaled a mixture of 35% CO2 and 65% O2 for 30 seconds through a face mask. They also breathed for 30 seconds through a valve reducing the diameter of the airway. A double-blind, counterbalanced, randomized design was used. Results: In spite of important similarities between the two interventions, including the induction of equal amounts of subjective respiratory distress, carbon dioxide inhalation was significantly more potent than increased airway resistance in provoking panic in the anxiety disorder patients. The patients with panic disorder were significantly more sensitive to CO2 than were the patients with social phobia or the normal subjects. Conclusions: Carbon dioxide inhalation appears to have a specific panicogenic effect in panic patients that goes beyond simple breathlessness.

Original languageEnglish (US)
Pages (from-to)250-257
Number of pages8
JournalAmerican Journal of Psychiatry
Volume150
Issue number2
StatePublished - 1993
Externally publishedYes

Fingerprint

Panic
Carbon Dioxide
Panic Disorder
Anxiety Disorders
Inhalation
Airway Resistance
Masks
Dyspnea

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Papp, L. A., Klein, D. F., Martinez, J., Schneier, F., Cole, R., Liebowitz, M. R., ... Gorman, J. M. (1993). Diagnostic and substance specificity of carbon-dioxide-induced panic. American Journal of Psychiatry, 150(2), 250-257.

Diagnostic and substance specificity of carbon-dioxide-induced panic. / Papp, Laszlo A.; Klein, Donald F.; Martinez, Jose; Schneier, Frank; Cole, Randolph; Liebowitz, Michael R.; Hollander, Eric; Fyer, Abby J.; Jordan, Fanchea; Gorman, Jack M.

In: American Journal of Psychiatry, Vol. 150, No. 2, 1993, p. 250-257.

Research output: Contribution to journalArticle

Papp, LA, Klein, DF, Martinez, J, Schneier, F, Cole, R, Liebowitz, MR, Hollander, E, Fyer, AJ, Jordan, F & Gorman, JM 1993, 'Diagnostic and substance specificity of carbon-dioxide-induced panic', American Journal of Psychiatry, vol. 150, no. 2, pp. 250-257.
Papp LA, Klein DF, Martinez J, Schneier F, Cole R, Liebowitz MR et al. Diagnostic and substance specificity of carbon-dioxide-induced panic. American Journal of Psychiatry. 1993;150(2):250-257.
Papp, Laszlo A. ; Klein, Donald F. ; Martinez, Jose ; Schneier, Frank ; Cole, Randolph ; Liebowitz, Michael R. ; Hollander, Eric ; Fyer, Abby J. ; Jordan, Fanchea ; Gorman, Jack M. / Diagnostic and substance specificity of carbon-dioxide-induced panic. In: American Journal of Psychiatry. 1993 ; Vol. 150, No. 2. pp. 250-257.
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