Diagnostic and Prognostic Utility of Optical Coherence Tomography in Patients With Sellar/Suprasellar Lesions with Chiasm Impingement: A Systematic Review/ Meta-Analyses

Seth S. Jeong, Abigail Funari, Vijay Agarwal

Research output: Contribution to journalReview articlepeer-review

Abstract

Background: In this review, we appraised the current literature on the utility of optical coherence tomography (OCT) as a diagnostic and predictive factor for postoperative visual function outcomes in patients with sellar/suprasellar lesions with chiasmal impingement. Methods: A systematic search of PubMed, CINAHL, Scopus, and Cochrane Library was conducted following PRISMA guidelines. Included studies described diagnostic or prognostic utility of OCT in patients with sellar/suprasellar lesions with chiasmal impingement. Meta-analysis was represented as mean difference (MD) with 95% confidence intervals. Meta-regression was performed to determine predictive factors of visual outcomes. Results: Forty-eight articles were identified for final pooled analysis, representing a total of 2435 patients with compressive sellar/suprasellar lesions and 952 healthy controls. Mean age was 43.3 (11.4) years, with 1494 (48.8%) male and 1566 (51.2%) female patients. Mean retinal nerve fiber layer (RNFL) was significantly different in the study population compared with healthy controls (75.8 μ [13.2] vs. 91.4 μ [10.8], P < 0.00001). The nasal segment of RNFL had the largest mean difference (MD –9.76 [–12.39, –7.13], P < 0.0001). Visual acuity, visual field mean deviation, and visual field pattern standard deviation all showed significant differences between the study population and healthy controls as well (P < 0.0001). Meta-regressions showed significant predictive capability of preoperative RNFL in determining visual function outcome (P < 0.05). Conclusions: Our findings provide promising support for the growing evidence that OCT parameters can be utilized as both a diagnostic and prognostic tool for patients with compression of the optic apparatus. There is a need for further studies to gain a better understanding of OCTs and to improve patient outcomes.

Original languageEnglish (US)
Pages (from-to)163-176.e2
JournalWorld Neurosurgery
Volume162
DOIs
StatePublished - Jun 2022

Keywords

  • Lesions
  • OCT
  • Optical coherence tomography
  • Pituitary
  • Suprasellar
  • Tumor

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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