Diagnostic and prognostic tests in systemic lupus erythematosus

Natalia Vasquez-Canizares, Dawn M. Wahezi, Chaim Putterman

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease characterized by autoantibodies directed against numerous self-nuclear antigens. Because of the heterogeneous nature of lupus, it has been challenging to identify markers that are sensitive and specific enough for its diagnosis and monitoring. However, with the sequencing of the human genome, rapid development of high-throughput approaches has allowed for a better understanding of the etiopathogenesis of complex diseases, including SLE. Here we present a review of the latest advancements in biomarker discovery during the “omics” era, using these novel technologies, for assisting in the diagnosis and prognosis of patients with SLE.

Original languageEnglish (US)
Pages (from-to)351-363
Number of pages13
JournalBest Practice and Research: Clinical Rheumatology
Volume31
Issue number3
DOIs
StatePublished - Jun 2017

Keywords

  • Biomarkers
  • Epigenetics
  • Genomics
  • Lupus nephritis
  • Metabolomics
  • Proteomics
  • Systemic lupus erythematosus
  • Transcriptomics

ASJC Scopus subject areas

  • Rheumatology

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