Diagnostic and prognostic tests in systemic lupus erythematosus

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease characterized by autoantibodies directed against numerous self-nuclear antigens. Because of the heterogeneous nature of lupus, it has been challenging to identify markers that are sensitive and specific enough for its diagnosis and monitoring. However, with the sequencing of the human genome, rapid development of high-throughput approaches has allowed for a better understanding of the etiopathogenesis of complex diseases, including SLE. Here we present a review of the latest advancements in biomarker discovery during the “omics“ era, using these novel technologies, for assisting in the diagnosis and prognosis of patients with SLE.

Original languageEnglish (US)
JournalBest Practice and Research: Clinical Rheumatology
DOIs
StateAccepted/In press - 2017

Fingerprint

Routine Diagnostic Tests
Systemic Lupus Erythematosus
Nuclear Antigens
Autoantigens
Human Genome
Autoantibodies
Autoimmune Diseases
Biomarkers
Technology

Keywords

  • Biomarkers
  • Epigenetics
  • Genomics
  • Lupus nephritis
  • Metabolomics
  • Proteomics
  • Systemic lupus erythematosus
  • Transcriptomics

ASJC Scopus subject areas

  • Rheumatology

Cite this

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title = "Diagnostic and prognostic tests in systemic lupus erythematosus",
abstract = "Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease characterized by autoantibodies directed against numerous self-nuclear antigens. Because of the heterogeneous nature of lupus, it has been challenging to identify markers that are sensitive and specific enough for its diagnosis and monitoring. However, with the sequencing of the human genome, rapid development of high-throughput approaches has allowed for a better understanding of the etiopathogenesis of complex diseases, including SLE. Here we present a review of the latest advancements in biomarker discovery during the “omics“ era, using these novel technologies, for assisting in the diagnosis and prognosis of patients with SLE.",
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AU - Putterman, Chaim

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AB - Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease characterized by autoantibodies directed against numerous self-nuclear antigens. Because of the heterogeneous nature of lupus, it has been challenging to identify markers that are sensitive and specific enough for its diagnosis and monitoring. However, with the sequencing of the human genome, rapid development of high-throughput approaches has allowed for a better understanding of the etiopathogenesis of complex diseases, including SLE. Here we present a review of the latest advancements in biomarker discovery during the “omics“ era, using these novel technologies, for assisting in the diagnosis and prognosis of patients with SLE.

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