Diagnosis of palmar hyperhidrosis via questionnaire without physical examination

Steven M. Keller, Riccardo Bello, Betsy Vibert, Gary Swergold, Robert D. Burk

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objectives: In order to determine the reliability of a self-administered instrument to diagnose excessive sweating conditions, including palmar hyperhidrosis (PH), we designed two successive questionnaires and compared responses with physical examination and sweat measurement in normal volunteers and a cohort of patients with documented PH. The reliable diagnosis of PH via questionnaire would enable molecular epidemiological studies without the need for physical examination or direct sweat measurement. Methods: Subjects self identified as either normal or affected by PH. Each completed one or both questionnaires and underwent physical examination. Sweat production from the thenar eminence and forehead was measured at rest and following mental/emotional stress. Correlation among sweat measurement, physical examination, and questionnaire score was assessed. Results: Forty-seven subjects enrolled in the study, 29 of whom underwent sweat measurements. The participants' perception of whether they were affected agreed with the examiner's visual and tactile observation of PH in all cases (P < 0.0005). The mean peak sweat rate for those participants with PH was 1.59 mg/cm2/min, while that of the normal cohort was 0.37 mg/cm2/min (P = 0.001). The mean questionnaire #1 and #2 scores for those participants with PH and the normal cohort was 7.10 versus 0.36 (P = 0.0005) and 5.145 versus 0.045 (P = 0.0005), respectively. Peak sweat rate correlated with questionnaire score (Pearson correlation coefficient = 0.723). Interpretation: Palmar hyperhidrosis can be accurately diagnosed via questionnaire. Molecular epidemiological studies of PH may be reliably conducted without the need for direct physical examination.

Original languageEnglish (US)
Pages (from-to)175-181
Number of pages7
JournalClinical Autonomic Research
Volume19
Issue number3
DOIs
StatePublished - Jun 2009

Fingerprint

Hyperhidrosis
Physical Examination
Sweat
Epidemiologic Studies
Surveys and Questionnaires
Sweating
Forehead
Touch
Psychological Stress
Healthy Volunteers
Observation

Keywords

  • Diagnosis
  • Hyperhidrosis
  • Palmar
  • Questionnaire
  • Sweating measurement

ASJC Scopus subject areas

  • Clinical Neurology
  • Endocrine and Autonomic Systems

Cite this

Diagnosis of palmar hyperhidrosis via questionnaire without physical examination. / Keller, Steven M.; Bello, Riccardo; Vibert, Betsy; Swergold, Gary; Burk, Robert D.

In: Clinical Autonomic Research, Vol. 19, No. 3, 06.2009, p. 175-181.

Research output: Contribution to journalArticle

Keller, Steven M. ; Bello, Riccardo ; Vibert, Betsy ; Swergold, Gary ; Burk, Robert D. / Diagnosis of palmar hyperhidrosis via questionnaire without physical examination. In: Clinical Autonomic Research. 2009 ; Vol. 19, No. 3. pp. 175-181.
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