Diagnosis of intra-abdominal and mediastinal sarcoidosis with EUS-guided FNA

Hazar Michael, Sammy Ho, Bonnie Pollack, Mala Gupta, Frank Gress

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background: In the presence of a compatible clinical picture, the diagnosis of sarcoidosis requires pathologic confirmation of noncaseating epithelioid granuloma in affected tissues. The standard procedure of choice for most patients is a bronchoscopy with transbronchial biopsy (TBB), which has a diagnostic yield of 40% to 90%. The lowest yield with TBB is in cases that present with predominant mediastinal or intra-abdominal lymphadenopathy (LN) and minimal parenchymal lung involvement. Objective: To study the diagnostic yield of EUS-guided FNA in diagnosing sarcoidosis with predominant LN or masses. Design: Retrospective chart review. Setting: Teaching university hospital. Patients: Analysis of 21 consecutive patients with sarcoidosis and predominant mediastinal and/or intra-abdominal LN or masses who underwent EUS-guided FNA. Results: EUS-guided FNA diagnosed sarcoidosis in 18 of 21 patients (86%). In 3 patients, EUS-guided FNA was either not diagnostic or inconclusive, and patients underwent mediastinoscopy with lymphadenectomy, which established the diagnosis of sarcoidosis. Seven of the 21 patients (33%) had intra-abdominal LN and/or masses, and EUS-guided FNA of the intra-abdominal pathology was diagnostic of sarcoidosis in 4 of the 7 patients (57%). Four of the 21 patients (19%) had a history of malignancy, and use of EUS-guided FNA helped in ruling out the recurrence of malignancy in 3 of the 4 patients (75%). Limitations: Mycobacterial and fungal culture was not obtained in all patients. Conclusions: EUS-guided FNA offers a practical, minimally invasive technique for the diagnosis of sarcoidosis in patients who present with predominant mediastinal and/or intra-abdominal LN or masses.

Original languageEnglish (US)
Pages (from-to)28-34
Number of pages7
JournalGastrointestinal Endoscopy
Volume67
Issue number1
DOIs
StatePublished - Jan 2008
Externally publishedYes

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Endoscopic Ultrasound-Guided Fine Needle Aspiration
Sarcoidosis
Mediastinoscopy
Biopsy
Bronchoscopy
Granuloma
Lymph Node Excision
Teaching Hospitals

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Diagnosis of intra-abdominal and mediastinal sarcoidosis with EUS-guided FNA. / Michael, Hazar; Ho, Sammy; Pollack, Bonnie; Gupta, Mala; Gress, Frank.

In: Gastrointestinal Endoscopy, Vol. 67, No. 1, 01.2008, p. 28-34.

Research output: Contribution to journalArticle

Michael, Hazar ; Ho, Sammy ; Pollack, Bonnie ; Gupta, Mala ; Gress, Frank. / Diagnosis of intra-abdominal and mediastinal sarcoidosis with EUS-guided FNA. In: Gastrointestinal Endoscopy. 2008 ; Vol. 67, No. 1. pp. 28-34.
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abstract = "Background: In the presence of a compatible clinical picture, the diagnosis of sarcoidosis requires pathologic confirmation of noncaseating epithelioid granuloma in affected tissues. The standard procedure of choice for most patients is a bronchoscopy with transbronchial biopsy (TBB), which has a diagnostic yield of 40{\%} to 90{\%}. The lowest yield with TBB is in cases that present with predominant mediastinal or intra-abdominal lymphadenopathy (LN) and minimal parenchymal lung involvement. Objective: To study the diagnostic yield of EUS-guided FNA in diagnosing sarcoidosis with predominant LN or masses. Design: Retrospective chart review. Setting: Teaching university hospital. Patients: Analysis of 21 consecutive patients with sarcoidosis and predominant mediastinal and/or intra-abdominal LN or masses who underwent EUS-guided FNA. Results: EUS-guided FNA diagnosed sarcoidosis in 18 of 21 patients (86{\%}). In 3 patients, EUS-guided FNA was either not diagnostic or inconclusive, and patients underwent mediastinoscopy with lymphadenectomy, which established the diagnosis of sarcoidosis. Seven of the 21 patients (33{\%}) had intra-abdominal LN and/or masses, and EUS-guided FNA of the intra-abdominal pathology was diagnostic of sarcoidosis in 4 of the 7 patients (57{\%}). Four of the 21 patients (19{\%}) had a history of malignancy, and use of EUS-guided FNA helped in ruling out the recurrence of malignancy in 3 of the 4 patients (75{\%}). Limitations: Mycobacterial and fungal culture was not obtained in all patients. Conclusions: EUS-guided FNA offers a practical, minimally invasive technique for the diagnosis of sarcoidosis in patients who present with predominant mediastinal and/or intra-abdominal LN or masses.",
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