Diagnosis and management of gastrointestinal neuroendocrine tumors.

I. M. Modlin, M. D. Basson, Sridhar Mani

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Neuroendocrine tumors of the gastrointestinal tract pose substantial diagnostic and therapeutic challenges. The numerous biologically active peptides and amines produced by these lesions generate complex clinical syndromes. Unfortunately, little is known regarding the genesis of these lesions. Recent advances in understanding of the pathobiology of these lesions has facilitated characterization of the biochemistry of tumor secretions. Similarly, pharmacological blockade of tumor bioactivity using somatostatin analogs, pharmacotherapeutic probes, or specific antagonists has enhanced treatment options. Effective biochemical palliation of tumor symptoms has in turn motivated a more aggressive approach to cytoreduction of these tumors by surgery or hepatic embolization. The combination of chemical blockade and surgical therapy may permit more extended and symptom-free survival for a significant proportion of patients. We evaluate the basic principles of diagnosis and management of gastrointestinal neuroendocrine tumors.

Original languageEnglish (US)
Pages (from-to)59-70
Number of pages12
JournalThe Gastroenterologist
Volume1
Issue number1
StatePublished - Mar 1993
Externally publishedYes

Fingerprint

Neuroendocrine Tumors
Neoplasms
Somatostatin
Biochemistry
Amines
Gastrointestinal Tract
Therapeutics
Pharmacology
Peptides
Survival
Liver

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Diagnosis and management of gastrointestinal neuroendocrine tumors. / Modlin, I. M.; Basson, M. D.; Mani, Sridhar.

In: The Gastroenterologist, Vol. 1, No. 1, 03.1993, p. 59-70.

Research output: Contribution to journalArticle

Modlin, I. M. ; Basson, M. D. ; Mani, Sridhar. / Diagnosis and management of gastrointestinal neuroendocrine tumors. In: The Gastroenterologist. 1993 ; Vol. 1, No. 1. pp. 59-70.
@article{a1e9ccf0fa9a4447afdd5d369c254ad3,
title = "Diagnosis and management of gastrointestinal neuroendocrine tumors.",
abstract = "Neuroendocrine tumors of the gastrointestinal tract pose substantial diagnostic and therapeutic challenges. The numerous biologically active peptides and amines produced by these lesions generate complex clinical syndromes. Unfortunately, little is known regarding the genesis of these lesions. Recent advances in understanding of the pathobiology of these lesions has facilitated characterization of the biochemistry of tumor secretions. Similarly, pharmacological blockade of tumor bioactivity using somatostatin analogs, pharmacotherapeutic probes, or specific antagonists has enhanced treatment options. Effective biochemical palliation of tumor symptoms has in turn motivated a more aggressive approach to cytoreduction of these tumors by surgery or hepatic embolization. The combination of chemical blockade and surgical therapy may permit more extended and symptom-free survival for a significant proportion of patients. We evaluate the basic principles of diagnosis and management of gastrointestinal neuroendocrine tumors.",
author = "Modlin, {I. M.} and Basson, {M. D.} and Sridhar Mani",
year = "1993",
month = "3",
language = "English (US)",
volume = "1",
pages = "59--70",
journal = "Gastroenterologist",
issn = "1065-2477",
publisher = "Little Brown & Co",
number = "1",

}

TY - JOUR

T1 - Diagnosis and management of gastrointestinal neuroendocrine tumors.

AU - Modlin, I. M.

AU - Basson, M. D.

AU - Mani, Sridhar

PY - 1993/3

Y1 - 1993/3

N2 - Neuroendocrine tumors of the gastrointestinal tract pose substantial diagnostic and therapeutic challenges. The numerous biologically active peptides and amines produced by these lesions generate complex clinical syndromes. Unfortunately, little is known regarding the genesis of these lesions. Recent advances in understanding of the pathobiology of these lesions has facilitated characterization of the biochemistry of tumor secretions. Similarly, pharmacological blockade of tumor bioactivity using somatostatin analogs, pharmacotherapeutic probes, or specific antagonists has enhanced treatment options. Effective biochemical palliation of tumor symptoms has in turn motivated a more aggressive approach to cytoreduction of these tumors by surgery or hepatic embolization. The combination of chemical blockade and surgical therapy may permit more extended and symptom-free survival for a significant proportion of patients. We evaluate the basic principles of diagnosis and management of gastrointestinal neuroendocrine tumors.

AB - Neuroendocrine tumors of the gastrointestinal tract pose substantial diagnostic and therapeutic challenges. The numerous biologically active peptides and amines produced by these lesions generate complex clinical syndromes. Unfortunately, little is known regarding the genesis of these lesions. Recent advances in understanding of the pathobiology of these lesions has facilitated characterization of the biochemistry of tumor secretions. Similarly, pharmacological blockade of tumor bioactivity using somatostatin analogs, pharmacotherapeutic probes, or specific antagonists has enhanced treatment options. Effective biochemical palliation of tumor symptoms has in turn motivated a more aggressive approach to cytoreduction of these tumors by surgery or hepatic embolization. The combination of chemical blockade and surgical therapy may permit more extended and symptom-free survival for a significant proportion of patients. We evaluate the basic principles of diagnosis and management of gastrointestinal neuroendocrine tumors.

UR - http://www.scopus.com/inward/record.url?scp=0027567395&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027567395&partnerID=8YFLogxK

M3 - Article

C2 - 8049881

AN - SCOPUS:0027567395

VL - 1

SP - 59

EP - 70

JO - Gastroenterologist

JF - Gastroenterologist

SN - 1065-2477

IS - 1

ER -