Diabetes mellitus and inflammation

Eric Lontchi-Yimagou, Eugene Sobngwi, Tandi E. Matsha, Andre Pascal Kengne

Research output: Contribution to journalArticlepeer-review

292 Scopus citations

Abstract

Type 2 diabetes mellitus (T2DM) is increasingly common worldwide. Related complications account for increased morbidity and mortality, and enormous healthcare spending. Knowledge of the pathophysiological derangements involved in the occurrence of diabetes and related complications is critical for successful prevention and control solutions. Epidemiologic studies have established an association between inflammatory biomarkers and the occurrence of T2DM and complications. Adipose tissue appears to be a major site of production of those inflammatory biomarkers, as a result of the cross-talk between adipose cells, macrophages, and other immune cells that infiltrate the expanding adipose tissue. The triggering mechanisms of the inflammation in T2DM are still ill-understood. Inflammatory response likely contributes to T2DM occurrence by causing insulin resistance, and is in turn intensified in the presence of hyperglycemia to promote long-term complications of diabetes. Targeting inflammatory pathways could possibly be a component of the strategies to prevent and control diabetes and related complications.

Original languageEnglish (US)
Pages (from-to)435-444
Number of pages10
JournalCurrent diabetes reports
Volume13
Issue number3
DOIs
StatePublished - Jun 2013
Externally publishedYes

Keywords

  • Adipocytes
  • Adipokines
  • Biomarkers
  • Cytokines
  • Diabetes mellitus
  • Inflammation
  • Interleukin

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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