Diabetes insipidus associated with hemophagocytic lymphohistiocytosis: First case report

Utpal Pajvani, Michael L. Lipton, Martin M. Grajower

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Objective: To report the first case of central diabetes insipidus associated with hemophagocytic lympho-histiocytosis. Methods: We describe the clinical course of a 75-year-old woman who developed febrile illness 1 month after receiving the H1N1 influenza vaccination. Shortly thereafter, she developed central diabetes insipidus, which responded to treatment with intranasal desmopressin acetate. She was then hospitalized with another febrile illness and diagnosed with hemophagocytic lymphohistiocytosis. Results: Magnetic resonance imaging of the pituitary gland was significant for plaquelike meningeal enhancement and thickening surrounding the infundibulum, which has been previously reported as a manifestation of histiocytosis. Conclusion: We believe this is the first case of central diabetes insipidus associated with hemophagocytic lymphohistiocytosis.

Original languageEnglish (US)
Pages (from-to)e118-e122
JournalEndocrine Practice
Volume17
Issue number5
DOIs
StatePublished - Sep 1 2011

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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