Diabetes genetic predisposition score and cardiovascular complications among patientswith type 2 diabetes

Qibin Qi, James B. Meigs, Kathryn M. Rexrode, Frank B. Hu, Lu Qi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

OBJECTIVEdTo examine the association between genetic predisposition to type 2 diabetes (T2D) and risk of cardiovascular disease (CVD) among patients with T2D. RESEARCH DESIGN AND METHODSdThe current study included 1,012 men and 1,310 women with T2D from the Health Professionals Follow-up Study and Nurses' Health Study, including 677 patients with CVD and 1,645 non-CVD control subjects. A genetic predisposition score (GPS) was calculated on the basis of 36 established independent diabetespredisposing variants. RESULTSdEach additional diabetes-risk allele in the GPS was associated with a 3% increased risk of CVD (odds ratio [OR] 1.03 [95% CI 1.00-1.06]). The OR was 1.47 (1.11-1.95) for CVD risk by comparing extreme quartiles of the GPS (P for trend = 0.01).We also found that the GPS was positively associated with hemoglobin A1c levels (P = 0.009). CONCLUSIONSdGenetic predisposition to T2D is associated with an increased risk of cardiovascular complications in patients with T2D.

Original languageEnglish (US)
Pages (from-to)737-739
Number of pages3
JournalDiabetes Care
Volume36
Issue number3
DOIs
StatePublished - Mar 2013
Externally publishedYes

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Genetic Predisposition to Disease
Type 2 Diabetes Mellitus
Cardiovascular Diseases
Odds Ratio
Health
Hemoglobins
Alleles
Nurses

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

Diabetes genetic predisposition score and cardiovascular complications among patientswith type 2 diabetes. / Qi, Qibin; Meigs, James B.; Rexrode, Kathryn M.; Hu, Frank B.; Qi, Lu.

In: Diabetes Care, Vol. 36, No. 3, 03.2013, p. 737-739.

Research output: Contribution to journalArticle

Qi, Qibin ; Meigs, James B. ; Rexrode, Kathryn M. ; Hu, Frank B. ; Qi, Lu. / Diabetes genetic predisposition score and cardiovascular complications among patientswith type 2 diabetes. In: Diabetes Care. 2013 ; Vol. 36, No. 3. pp. 737-739.
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N2 - OBJECTIVEdTo examine the association between genetic predisposition to type 2 diabetes (T2D) and risk of cardiovascular disease (CVD) among patients with T2D. RESEARCH DESIGN AND METHODSdThe current study included 1,012 men and 1,310 women with T2D from the Health Professionals Follow-up Study and Nurses' Health Study, including 677 patients with CVD and 1,645 non-CVD control subjects. A genetic predisposition score (GPS) was calculated on the basis of 36 established independent diabetespredisposing variants. RESULTSdEach additional diabetes-risk allele in the GPS was associated with a 3% increased risk of CVD (odds ratio [OR] 1.03 [95% CI 1.00-1.06]). The OR was 1.47 (1.11-1.95) for CVD risk by comparing extreme quartiles of the GPS (P for trend = 0.01).We also found that the GPS was positively associated with hemoglobin A1c levels (P = 0.009). CONCLUSIONSdGenetic predisposition to T2D is associated with an increased risk of cardiovascular complications in patients with T2D.

AB - OBJECTIVEdTo examine the association between genetic predisposition to type 2 diabetes (T2D) and risk of cardiovascular disease (CVD) among patients with T2D. RESEARCH DESIGN AND METHODSdThe current study included 1,012 men and 1,310 women with T2D from the Health Professionals Follow-up Study and Nurses' Health Study, including 677 patients with CVD and 1,645 non-CVD control subjects. A genetic predisposition score (GPS) was calculated on the basis of 36 established independent diabetespredisposing variants. RESULTSdEach additional diabetes-risk allele in the GPS was associated with a 3% increased risk of CVD (odds ratio [OR] 1.03 [95% CI 1.00-1.06]). The OR was 1.47 (1.11-1.95) for CVD risk by comparing extreme quartiles of the GPS (P for trend = 0.01).We also found that the GPS was positively associated with hemoglobin A1c levels (P = 0.009). CONCLUSIONSdGenetic predisposition to T2D is associated with an increased risk of cardiovascular complications in patients with T2D.

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