Diabetes and restenosis

Scott Wilson, Pasquale Mone, Urna Kansakar, Stanislovas S. Jankauskas, Kwame Donkor, Ayobami Adebayo, Fahimeh Varzideh, Michael Eacobacci, Jessica Gambardella, Angela Lombardi, Gaetano Santulli

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Restenosis, defined as the re-narrowing of an arterial lumen after revascularization, represents an increasingly important issue in clinical practice. Indeed, as the number of stent placements has risen to an estimate that exceeds 3 million annually worldwide, revascularization procedures have become much more common. Several investigators have demonstrated that vessels in patients with diabetes mellitus have an increased risk restenosis. Here we present a systematic overview of the effects of diabetes on in-stent restenosis. Current classification and updated epidemiology of restenosis are discussed, alongside the main mechanisms underlying the pathophysiology of this event. Then, we summarize the clinical presentation of restenosis, emphasizing the importance of glycemic control in diabetic patients. Indeed, in diabetic patients who underwent revascularization procedures a proper glycemic control remains imperative.

Original languageEnglish (US)
Article number23
JournalCardiovascular Diabetology
Issue number1
StatePublished - Dec 2022


  • ACS
  • BMS
  • CABG
  • DES
  • Diabetes
  • Endothelial dysfunction
  • Epidemiology
  • Hyperglycemia
  • PCI
  • Restenosis
  • Stent
  • VSMC

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine


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