Dexamethasone inhibits macrophage accumulation after balloon arterial injury in cholesterol fed rabbits

Michael Poon, S. David Gertz, John T. Fallon, Pete Wiegman, Joan W. Berman, Ian J. Sarembock, Mark B. Taubman

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Macrophages play a critical role in the development and progression of atherosclerosis. This study was designed to examine the effect of the glucocorticoid, dexamethasone, (Dex), on macrophage accumulation after acute arterial injury. Twenty New Zealand white rabbits were fed a 2% cholesterol, 6% peanut oil, rabbit chow diet for one month prior to bilateral balloon dilatation of the femoral arteries. Ten rabbits received Dex (1 mg/kg, im.) the day before and then daily for 7 days after arterial injury; control rabbits received vehicle only. Seven days after injury, Dex treatment resulted in a 96% and 77% reduction (P < 0.002) in the mean number of macrophages accumulating in the intima and media, respectively. This effect was apparently not due to a reduction in the number of circulating monocytes or to the ability of monocytes from Dex treated animals to adhere to endothelium or migrate in response to a chemotactic signal, determined in vitro under static conditions. It was associated with a 61% reduction in monocyte chemoattractant protein-1 (MCP-1) antigen (P < 0.004) in the injured arterial wall (media + intima). Glucocorticoids may be useful in attenuating the inflammatory response and subsequent foam-cell accumulation after arterial injury.

Original languageEnglish (US)
Pages (from-to)371-380
Number of pages10
JournalAtherosclerosis
Volume155
Issue number2
DOIs
StatePublished - Mar 24 2001

Keywords

  • Arterial injury
  • Glucocorticoids
  • Hypercholesterolemic rabbits
  • Intimal hyperplasia
  • Macrophages
  • Monocyte chemoattractant protein-1

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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