Developmental loss of MeCP2 from VIP interneurons impairs cortical function and behavior

James M. Mossner, Renata Batista-Brito, Rima Pant, Jessica A. Cardin

Research output: Contribution to journalArticle

Abstract

Rett Syndrome is a devastating neurodevelopmental disorder resulting from mutations in the gene MECP2. Mutations of Mecp2 restricted to GABAergic cell types largely replicate the behavioral phenotypes associated with mouse models of Rett Syndrome, suggesting a pathophysiological role for inhibitory interneurons. Recent work has suggested that vasoactive intestinal peptide-expressing (VIP) interneurons may play a critical role in the proper development and function of cortical circuits, making them a potentially key point of vulnerability in neurodevelopmental disorders. However, little is known about the role of VIP interneurons in Rett Syndrome. Here we find that loss of MeCP2 specifically from VIP interneurons replicates key neural and behavioral phenotypes observed following global Mecp2 loss of function.

Original languageEnglish (US)
Article numbere55639
JournaleLife
Volume9
DOIs
StatePublished - Apr 2020

Keywords

  • GABAergic interneurons
  • MeCP2
  • Parvalbumin
  • Rett Syndrome
  • Social behavior
  • Somatostatin
  • State-dependent
  • VIP
  • Vasoactive intestinal peptide

ASJC Scopus subject areas

  • Neuroscience(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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