Developmental injury to the cerebellum following perinatal Borna disease virus infection

Jan R. Bautista, Steven A. Rubin, Timothy H. Moran, Gary J. Schwartz, Kathryn M. Carbone

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

In rats infected as neonates, Borna disease virus (BDV) infection causes neuroanatomical, behavioral and physiological abnormalities without encephalitis. Neonatal infection with BDV provides a powerful model for studying the effects of virus replication on brain development without inflammation-induced brain damage. Here we report that neonatal BDV infection interfered with cerebellar development in the Lewis rat. Based on cerebellar cross-sectional area measurements, abnormal cerebellar growth was first noted between 7 and 14 days after infection. Reactive astrocytosis was evident by three days after infection, even without encephalitis, and even before identification of viral proteins in the cerebellum. While neonatal BDV infection caused a significant loss in granule cells, infected granule cells were not identified. BDV proteins were readily detected in the Purkinje cells. Thus, persistent BDV infection of Purkinje cells, but not granule cells, was associated with loss of granule cells during cerebellar development, in the absence of encephalitis.

Original languageEnglish (US)
Pages (from-to)45-53
Number of pages9
JournalDevelopmental Brain Research
Volume90
Issue number1-2
DOIs
StatePublished - Dec 21 1995
Externally publishedYes

Fingerprint

Borna disease virus
Virus Diseases
Cerebellum
Encephalitis
Infant, Newborn, Diseases
Wounds and Injuries
Purkinje Cells
Infection
Gliosis
Viral Proteins
Virus Replication
Brain
Growth

Keywords

  • Boma disease virus
  • Brain
  • Cerebellum
  • Development
  • Granule cell
  • Neonatal infection
  • Neuron
  • Rat
  • Virus

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

Developmental injury to the cerebellum following perinatal Borna disease virus infection. / Bautista, Jan R.; Rubin, Steven A.; Moran, Timothy H.; Schwartz, Gary J.; Carbone, Kathryn M.

In: Developmental Brain Research, Vol. 90, No. 1-2, 21.12.1995, p. 45-53.

Research output: Contribution to journalArticle

Bautista, Jan R. ; Rubin, Steven A. ; Moran, Timothy H. ; Schwartz, Gary J. ; Carbone, Kathryn M. / Developmental injury to the cerebellum following perinatal Borna disease virus infection. In: Developmental Brain Research. 1995 ; Vol. 90, No. 1-2. pp. 45-53.
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