Developmental expression of survivin during embryonic submandibular salivary gland development.

T. Jaskoll, H. Chen, Y. Min Zhou, D. Wu, M. Melnick

Research output: Contribution to journalArticle

Abstract

BACKGROUND: The regulation of programmed cell death is critical to developmental homeostasis and normal morphogenesis of embryonic tissues. Survivin, a member of the inhibitors of apoptosis protein (IAP) family primarily expressed in embryonic cells, is both an anti-apoptosis and a pro-survival factor. Since our previous studies have demonstrated the importance of apoptosis during embryonic submandibular salivary gland (SMG) development, we postulated that survivin is a likely mediator of SMG epithelial cell survival. RESULTS: We investigated the developmental expression of survivin in Pseudoglandular (approximately E14), Canalicular (approximately E15) and Terminal Bud (approximately E17) Stage SMGs. We report a significant 26% increase in transcript levels between the Canalicular and Terminal Bud Stages. Immunohistochemical studies demonstrate nuclear-localized survivin protein in epithelial cells bounding forming lumina in Canalicular and Terminal Bud Stage SMGs. CONCLUSIONS: Survivin is known to be a pro-survival and anti-apoptotic factor. Given that survivin translocation into the nucleus is required for the induction of entry into the cell cycle and the inhibition of apoptosis, our demonstration of nuclear-localized survivin protein in presumptive ductal and proacinar lumen-bounding cells suggests that survivin may be a key mediator of embryonic SMG epithelial cell survival.

Original languageEnglish (US)
Pages (from-to)5
Number of pages1
JournalBMC Developmental Biology
Volume1
Issue number1
StatePublished - 2001
Externally publishedYes

Fingerprint

Submandibular Gland
Salivary Glands
Epithelial Cells
Apoptosis
Cell Survival
Inhibitor of Apoptosis Proteins
Morphogenesis
Cell Cycle
Proteins
Homeostasis
Cell Death

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Developmental expression of survivin during embryonic submandibular salivary gland development. / Jaskoll, T.; Chen, H.; Min Zhou, Y.; Wu, D.; Melnick, M.

In: BMC Developmental Biology, Vol. 1, No. 1, 2001, p. 5.

Research output: Contribution to journalArticle

Jaskoll, T, Chen, H, Min Zhou, Y, Wu, D & Melnick, M 2001, 'Developmental expression of survivin during embryonic submandibular salivary gland development.', BMC Developmental Biology, vol. 1, no. 1, pp. 5.
Jaskoll, T. ; Chen, H. ; Min Zhou, Y. ; Wu, D. ; Melnick, M. / Developmental expression of survivin during embryonic submandibular salivary gland development. In: BMC Developmental Biology. 2001 ; Vol. 1, No. 1. pp. 5.
@article{ea3d679c6d7b41d6ab736cbecd8aac0a,
title = "Developmental expression of survivin during embryonic submandibular salivary gland development.",
abstract = "BACKGROUND: The regulation of programmed cell death is critical to developmental homeostasis and normal morphogenesis of embryonic tissues. Survivin, a member of the inhibitors of apoptosis protein (IAP) family primarily expressed in embryonic cells, is both an anti-apoptosis and a pro-survival factor. Since our previous studies have demonstrated the importance of apoptosis during embryonic submandibular salivary gland (SMG) development, we postulated that survivin is a likely mediator of SMG epithelial cell survival. RESULTS: We investigated the developmental expression of survivin in Pseudoglandular (approximately E14), Canalicular (approximately E15) and Terminal Bud (approximately E17) Stage SMGs. We report a significant 26{\%} increase in transcript levels between the Canalicular and Terminal Bud Stages. Immunohistochemical studies demonstrate nuclear-localized survivin protein in epithelial cells bounding forming lumina in Canalicular and Terminal Bud Stage SMGs. CONCLUSIONS: Survivin is known to be a pro-survival and anti-apoptotic factor. Given that survivin translocation into the nucleus is required for the induction of entry into the cell cycle and the inhibition of apoptosis, our demonstration of nuclear-localized survivin protein in presumptive ductal and proacinar lumen-bounding cells suggests that survivin may be a key mediator of embryonic SMG epithelial cell survival.",
author = "T. Jaskoll and H. Chen and {Min Zhou}, Y. and D. Wu and M. Melnick",
year = "2001",
language = "English (US)",
volume = "1",
pages = "5",
journal = "BMC Developmental Biology",
issn = "1471-213X",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Developmental expression of survivin during embryonic submandibular salivary gland development.

AU - Jaskoll, T.

AU - Chen, H.

AU - Min Zhou, Y.

AU - Wu, D.

AU - Melnick, M.

PY - 2001

Y1 - 2001

N2 - BACKGROUND: The regulation of programmed cell death is critical to developmental homeostasis and normal morphogenesis of embryonic tissues. Survivin, a member of the inhibitors of apoptosis protein (IAP) family primarily expressed in embryonic cells, is both an anti-apoptosis and a pro-survival factor. Since our previous studies have demonstrated the importance of apoptosis during embryonic submandibular salivary gland (SMG) development, we postulated that survivin is a likely mediator of SMG epithelial cell survival. RESULTS: We investigated the developmental expression of survivin in Pseudoglandular (approximately E14), Canalicular (approximately E15) and Terminal Bud (approximately E17) Stage SMGs. We report a significant 26% increase in transcript levels between the Canalicular and Terminal Bud Stages. Immunohistochemical studies demonstrate nuclear-localized survivin protein in epithelial cells bounding forming lumina in Canalicular and Terminal Bud Stage SMGs. CONCLUSIONS: Survivin is known to be a pro-survival and anti-apoptotic factor. Given that survivin translocation into the nucleus is required for the induction of entry into the cell cycle and the inhibition of apoptosis, our demonstration of nuclear-localized survivin protein in presumptive ductal and proacinar lumen-bounding cells suggests that survivin may be a key mediator of embryonic SMG epithelial cell survival.

AB - BACKGROUND: The regulation of programmed cell death is critical to developmental homeostasis and normal morphogenesis of embryonic tissues. Survivin, a member of the inhibitors of apoptosis protein (IAP) family primarily expressed in embryonic cells, is both an anti-apoptosis and a pro-survival factor. Since our previous studies have demonstrated the importance of apoptosis during embryonic submandibular salivary gland (SMG) development, we postulated that survivin is a likely mediator of SMG epithelial cell survival. RESULTS: We investigated the developmental expression of survivin in Pseudoglandular (approximately E14), Canalicular (approximately E15) and Terminal Bud (approximately E17) Stage SMGs. We report a significant 26% increase in transcript levels between the Canalicular and Terminal Bud Stages. Immunohistochemical studies demonstrate nuclear-localized survivin protein in epithelial cells bounding forming lumina in Canalicular and Terminal Bud Stage SMGs. CONCLUSIONS: Survivin is known to be a pro-survival and anti-apoptotic factor. Given that survivin translocation into the nucleus is required for the induction of entry into the cell cycle and the inhibition of apoptosis, our demonstration of nuclear-localized survivin protein in presumptive ductal and proacinar lumen-bounding cells suggests that survivin may be a key mediator of embryonic SMG epithelial cell survival.

UR - http://www.scopus.com/inward/record.url?scp=0002126039&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0002126039&partnerID=8YFLogxK

M3 - Article

VL - 1

SP - 5

JO - BMC Developmental Biology

JF - BMC Developmental Biology

SN - 1471-213X

IS - 1

ER -