Developmental changes in calcium kinetics in children assessed using stable isotopes

Steven A. Abrams, Nora V. Esteban, Nancy E. Vieira, James B. Sidbury, Bonny L. Specker, Alfred L. Yergey

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Total exchangeable calcium pool size (TEP) and bone calcium accretion rate (Vo+) were measured using stable isotopes in healthy children and young adults. 42Ca or 46Ca was given intravenously to 10 children aged 10 months to 14 years and 3 women aged 23-33 years. Calcium kinetic parameters were determined using a two- or three-exponential curve of the resultant serum and urine tracer excesses. These data were compared with previously reported (radiotracer) kinetic studies of 21 children and 5 adults without known bone disease. Current results are comparable to those previously obtained, and the data from all studies were analyzed together. Total Vo+ was significantly greater in children aged 3-16 years than in adults (2.8 ± 1.6 versus 0.7 ± 0.2 g/day, p < 0.01). Both TEP and Vo+ were significantly correlated to age independently of variations in body weight (p < 0.01 for each). The ratio ko+ = Vo+/TEP was greater in children than adults (0.36 ± 0.15 versus 0.12 ± 0.03 day-1, p < 0.001). These data demonstrate increased bone flow of calcium associated with increases in exchangeable calcium pools in children compared to adults. Vo+ and TEP may be maximum in early adolescence, associated with peak rates of net calcium accretion. The use of stable isotopes permits the safe evaluation of calcium kinetics in patients of all ages.

Original languageEnglish (US)
Pages (from-to)287-293
Number of pages7
JournalJournal of Bone and Mineral Research
Volume7
Issue number3
StatePublished - Mar 1992
Externally publishedYes

Fingerprint

Isotopes
Calcium
Bone and Bones
Bone Diseases
Young Adult
Body Weight
Urine
tetraethylpyrazine
Serum

ASJC Scopus subject areas

  • Surgery

Cite this

Abrams, S. A., Esteban, N. V., Vieira, N. E., Sidbury, J. B., Specker, B. L., & Yergey, A. L. (1992). Developmental changes in calcium kinetics in children assessed using stable isotopes. Journal of Bone and Mineral Research, 7(3), 287-293.

Developmental changes in calcium kinetics in children assessed using stable isotopes. / Abrams, Steven A.; Esteban, Nora V.; Vieira, Nancy E.; Sidbury, James B.; Specker, Bonny L.; Yergey, Alfred L.

In: Journal of Bone and Mineral Research, Vol. 7, No. 3, 03.1992, p. 287-293.

Research output: Contribution to journalArticle

Abrams, SA, Esteban, NV, Vieira, NE, Sidbury, JB, Specker, BL & Yergey, AL 1992, 'Developmental changes in calcium kinetics in children assessed using stable isotopes', Journal of Bone and Mineral Research, vol. 7, no. 3, pp. 287-293.
Abrams SA, Esteban NV, Vieira NE, Sidbury JB, Specker BL, Yergey AL. Developmental changes in calcium kinetics in children assessed using stable isotopes. Journal of Bone and Mineral Research. 1992 Mar;7(3):287-293.
Abrams, Steven A. ; Esteban, Nora V. ; Vieira, Nancy E. ; Sidbury, James B. ; Specker, Bonny L. ; Yergey, Alfred L. / Developmental changes in calcium kinetics in children assessed using stable isotopes. In: Journal of Bone and Mineral Research. 1992 ; Vol. 7, No. 3. pp. 287-293.
@article{c34aaabea6584f0a940964160edbf307,
title = "Developmental changes in calcium kinetics in children assessed using stable isotopes",
abstract = "Total exchangeable calcium pool size (TEP) and bone calcium accretion rate (Vo+) were measured using stable isotopes in healthy children and young adults. 42Ca or 46Ca was given intravenously to 10 children aged 10 months to 14 years and 3 women aged 23-33 years. Calcium kinetic parameters were determined using a two- or three-exponential curve of the resultant serum and urine tracer excesses. These data were compared with previously reported (radiotracer) kinetic studies of 21 children and 5 adults without known bone disease. Current results are comparable to those previously obtained, and the data from all studies were analyzed together. Total Vo+ was significantly greater in children aged 3-16 years than in adults (2.8 ± 1.6 versus 0.7 ± 0.2 g/day, p < 0.01). Both TEP and Vo+ were significantly correlated to age independently of variations in body weight (p < 0.01 for each). The ratio ko+ = Vo+/TEP was greater in children than adults (0.36 ± 0.15 versus 0.12 ± 0.03 day-1, p < 0.001). These data demonstrate increased bone flow of calcium associated with increases in exchangeable calcium pools in children compared to adults. Vo+ and TEP may be maximum in early adolescence, associated with peak rates of net calcium accretion. The use of stable isotopes permits the safe evaluation of calcium kinetics in patients of all ages.",
author = "Abrams, {Steven A.} and Esteban, {Nora V.} and Vieira, {Nancy E.} and Sidbury, {James B.} and Specker, {Bonny L.} and Yergey, {Alfred L.}",
year = "1992",
month = "3",
language = "English (US)",
volume = "7",
pages = "287--293",
journal = "Journal of Bone and Mineral Research",
issn = "0884-0431",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Developmental changes in calcium kinetics in children assessed using stable isotopes

AU - Abrams, Steven A.

AU - Esteban, Nora V.

AU - Vieira, Nancy E.

AU - Sidbury, James B.

AU - Specker, Bonny L.

AU - Yergey, Alfred L.

PY - 1992/3

Y1 - 1992/3

N2 - Total exchangeable calcium pool size (TEP) and bone calcium accretion rate (Vo+) were measured using stable isotopes in healthy children and young adults. 42Ca or 46Ca was given intravenously to 10 children aged 10 months to 14 years and 3 women aged 23-33 years. Calcium kinetic parameters were determined using a two- or three-exponential curve of the resultant serum and urine tracer excesses. These data were compared with previously reported (radiotracer) kinetic studies of 21 children and 5 adults without known bone disease. Current results are comparable to those previously obtained, and the data from all studies were analyzed together. Total Vo+ was significantly greater in children aged 3-16 years than in adults (2.8 ± 1.6 versus 0.7 ± 0.2 g/day, p < 0.01). Both TEP and Vo+ were significantly correlated to age independently of variations in body weight (p < 0.01 for each). The ratio ko+ = Vo+/TEP was greater in children than adults (0.36 ± 0.15 versus 0.12 ± 0.03 day-1, p < 0.001). These data demonstrate increased bone flow of calcium associated with increases in exchangeable calcium pools in children compared to adults. Vo+ and TEP may be maximum in early adolescence, associated with peak rates of net calcium accretion. The use of stable isotopes permits the safe evaluation of calcium kinetics in patients of all ages.

AB - Total exchangeable calcium pool size (TEP) and bone calcium accretion rate (Vo+) were measured using stable isotopes in healthy children and young adults. 42Ca or 46Ca was given intravenously to 10 children aged 10 months to 14 years and 3 women aged 23-33 years. Calcium kinetic parameters were determined using a two- or three-exponential curve of the resultant serum and urine tracer excesses. These data were compared with previously reported (radiotracer) kinetic studies of 21 children and 5 adults without known bone disease. Current results are comparable to those previously obtained, and the data from all studies were analyzed together. Total Vo+ was significantly greater in children aged 3-16 years than in adults (2.8 ± 1.6 versus 0.7 ± 0.2 g/day, p < 0.01). Both TEP and Vo+ were significantly correlated to age independently of variations in body weight (p < 0.01 for each). The ratio ko+ = Vo+/TEP was greater in children than adults (0.36 ± 0.15 versus 0.12 ± 0.03 day-1, p < 0.001). These data demonstrate increased bone flow of calcium associated with increases in exchangeable calcium pools in children compared to adults. Vo+ and TEP may be maximum in early adolescence, associated with peak rates of net calcium accretion. The use of stable isotopes permits the safe evaluation of calcium kinetics in patients of all ages.

UR - http://www.scopus.com/inward/record.url?scp=0026522449&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026522449&partnerID=8YFLogxK

M3 - Article

C2 - 1585830

AN - SCOPUS:0026522449

VL - 7

SP - 287

EP - 293

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

SN - 0884-0431

IS - 3

ER -