Developmental aspects of the basal ganglia and therapeutic perspectives

Jana Velíšková, Olga I. Claudio, Aristea S. Galanopoulou, Andreas Kyrozis, Fred A. Lado, Teresa Ravizza, Libor Velíšek, Solomon L. Moshe

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Development and sex hormones play an important role in the expression of seizures. Sex-specific differences in the development of seizuresuppressing neuronal networks may account, at least in part, for age- and sex-related susceptibility to seizures. The substantia nigra pars reticulata is a site involved in the control of seizures. In adult male rats, there are two distinct GABAA sensitive regions within the substantia nigra pars reticulata, which mediate opposite effects in flurothyl seizures. Muscimol infused into the anterior region is anticonvulsant while similar infusions into the posterior region are proconvulsant. These two regions differ morphologically, and utilize different efferent networks. In contrast, in postnatal day 15 male rats, there is no such differentiation and muscimol infusions have only proconvulsant effects. The hallmark of the female substantia nigra pars reticulata is the fact that muscimol-mediated proconvulsant effects cannot be demonstrated in any region at any age. The sex-related difference in nigral seizure control may be related to the lack of testosterone in females. Accordingly, neonatal castration of males results in the loss of the "proconvulsant" region. The "male" type of the substantia nigra pars reticulata effects can be induced by exogenous testosterone administration in neonatally castrated male or in female rats. The phenotype of nigral GABAergic neurons, as characterized by GABAA receptor subunit composition, muscimol-induced electrophysiological responses, and connectivity of output networks may each be altered by the presence of testosterone. Better understanding of the influence of the endocrine system on brain development and neuronal activity may provide new insight into the treatment of age- and sex-dependent seizure disorders.

Original languageEnglish (US)
JournalEpileptic Disorders
Volume4
Issue numberSUPPL. 3
StatePublished - Dec 2002

Fingerprint

Basal Ganglia
Muscimol
Seizures
Testosterone
Substantia Nigra
Sex Characteristics
Flurothyl
Therapeutics
GABAergic Neurons
Endocrine System
Orchiectomy
Gonadal Steroid Hormones
GABA-A Receptors
Anticonvulsants
Epilepsy
Phenotype
Pars Reticulata
Brain

Keywords

  • Basal ganglia
  • Development
  • Epilepsy
  • GABA
  • Seizures
  • Sex
  • Substantia nigra
  • Testosterone

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Velíšková, J., Claudio, O. I., Galanopoulou, A. S., Kyrozis, A., Lado, F. A., Ravizza, T., ... Moshe, S. L. (2002). Developmental aspects of the basal ganglia and therapeutic perspectives. Epileptic Disorders, 4(SUPPL. 3).

Developmental aspects of the basal ganglia and therapeutic perspectives. / Velíšková, Jana; Claudio, Olga I.; Galanopoulou, Aristea S.; Kyrozis, Andreas; Lado, Fred A.; Ravizza, Teresa; Velíšek, Libor; Moshe, Solomon L.

In: Epileptic Disorders, Vol. 4, No. SUPPL. 3, 12.2002.

Research output: Contribution to journalArticle

Velíšková, J, Claudio, OI, Galanopoulou, AS, Kyrozis, A, Lado, FA, Ravizza, T, Velíšek, L & Moshe, SL 2002, 'Developmental aspects of the basal ganglia and therapeutic perspectives', Epileptic Disorders, vol. 4, no. SUPPL. 3.
Velíšková J, Claudio OI, Galanopoulou AS, Kyrozis A, Lado FA, Ravizza T et al. Developmental aspects of the basal ganglia and therapeutic perspectives. Epileptic Disorders. 2002 Dec;4(SUPPL. 3).
Velíšková, Jana ; Claudio, Olga I. ; Galanopoulou, Aristea S. ; Kyrozis, Andreas ; Lado, Fred A. ; Ravizza, Teresa ; Velíšek, Libor ; Moshe, Solomon L. / Developmental aspects of the basal ganglia and therapeutic perspectives. In: Epileptic Disorders. 2002 ; Vol. 4, No. SUPPL. 3.
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